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Effects of Walking and Heating on Vascular Function in Diabetic Patients

Obesity Clinical Trial

Official title:
Restoring Vasodilator Actions of Insulin in Patients With Type 2 Diabetes

Clinical Trial Summary

The purpose of the present study is to determine the effects of increased walking and lower body heating on leg vascular function in patients with type 2 diabetes (T2D).

Clinical Trial Description

The notion that habitual aerobic exercise increases insulin-induced vasodilation is largely founded on rodent studies, hence the urgent need for human studies, especially in patients with type 2 diabetes (T2D). For example, it remains unknown if increased walking, the most common form of physical activity, enhances skeletal muscle vasodilator actions of insulin in T2D. In addition, the molecular mechanisms by which exercise improves vasoreactivity to insulin have not been examined in humans. The investigators propose that in T2D patients who are sedentary (i.e., the vast majority), increased leg blood flow with walking or local heating signifies a vital strategy to correct vascular insulin resistance. This study will establish whether increased physical activity and associated hemodynamic forces (e.g., shear stress) are a direct form of vascular medicine in humans. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03203694
Study type Interventional
Source University of Missouri-Columbia
Contact
Status Completed
Phase N/A
Start date December 4, 2017
Completion date March 10, 2022
View Details
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