Obesity Clinical Trial
Official title:
Effect of Sucrose Versus High Fructose Corn Syrup on Cardiometabolic Risk: A Series of Systematic Reviews and Meta-Analyses of Controlled Trials
Verified date | March 2016 |
Source | University of Toronto |
Contact | n/a |
Is FDA regulated | No |
Health authority | Canada: Ethics Review Committe |
Study type | Observational |
The rise in high fructose corn syrup (HFCS) consumption over the past 40 years since its introduction as a popular sweetener in the United States has led to much concern regarding its contribution to the rise in obesity (1), diabetes (2) and related cardiometabolic disorders (3).Unlike sucrose which contains equal proportions of fructose and glucose bound by an α-glycosidic bond, HFCS contains 42-55% of fructose to glucose in a free (unbound) form (4). Despite these differences in composition, both sugars possess identical energy contribution on a gram to gram basis (4). However, the higher ratio of fructose to glucose in HFCS has led to the hypothesis that HFCS may uniquely contribute to cardiometabolic risk, more so than sucrose, through proposed differences in fructose metabolism, endocrine and hedonic properties (5). We will conduct a series of systematic reviews and meta-analyses to assess the role of HFCS versus sucrose under energy matched (isocaloric) conditions on cardiometabolic risk.
Status | Active, not recruiting |
Enrollment | 1 |
Est. completion date | June 2016 |
Est. primary completion date | June 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Trials in humans - Oral fructose-containing sugars intervention - Presence of an adequate comparator in isocaloric substitution - Diet duration >=7 days - Viable outcome data Exclusion Criteria: - Non-human trials - Observational studies - IV or parenteral fructose-containing sugars - Lack of suitable comparator (i.e. a comparator arm not including sucrose or HFCS in isocaloric substitution) - Diet duration <7 days - No viable outcome data |
N/A
Country | Name | City | State |
---|---|---|---|
Canada | The Toronto 3D (Diet, Digestive tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital | Toronto | Ontario |
Lead Sponsor | Collaborator |
---|---|
University of Toronto | Banting and Best Diabetes Centre (BBDC), Canadian Institutes of Health Research (CIHR), The Physicians' Services Incorporated Foundation |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Body weight and measures of adiposity analysis | Up to 20 years | No | |
Primary | Glycemic control analysis | Up to 20 years | No | |
Primary | Blood Lipids analysis | Up to 20 years | No | |
Primary | Blood pressure analysis | Up to 20 years | No | |
Primary | Uric acid analysis | Up to 20 years | No | |
Primary | Non-Alcoholic Fatty Liver Disease (NAFLD) and ectopic fat Analysis | Up to 20 years | No | |
Primary | Inflammation analysis | Up to 20 years | No |
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