Obesity Clinical Trial
Official title:
Effectiveness of Four Dietary Treatment Strategies for Metabolic Syndrome: a Prospective Randomized Trial
A single-center randomized trial at an academic medical center in Boston, Mass, of overweight or obese (body mass index: mean, 35; range, 27-42) adults aged 22 to 72 years with known hypertension, dyslipidemia, or fasting hyperglycemia. Participants were enrolled starting July 18, 2000, and randomized to 4 popular diet groups until January 24, 2002.
Objective: To assess adherence rates and the effectiveness of 4 popular diets (Atkins, Zone,
Weight Watchers, and Ornish) for weight loss and cardiac risk factor reduction.
Design, Setting, and Participants: A single-center randomized trial at an academic medical
center in Boston, Mass, of overweight or obese (body mass index: mean, 35; range, 27-42)
adults aged 22 to 72 years with known hypertension, dyslipidemia, or fasting hyperglycemia.
Participants were enrolled starting July 18, 2000, and randomized to 4 popular diet groups
until January 24, 2002.
Intervention: A total of 160 participants were randomly assigned to either Atkins
(carbohydrate restriction, n=40), Zone (macronutrient balance, n=40), Weight Watchers
(calorie restriction, n=40), or Ornish (fat restriction, n=40) diet groups. After 2 months
of maximum effort, participants selected their own levels of dietary adherence.
Main Outcome Measures: One-year changes in baseline weight and cardiac risk factors, and
self-selected dietary adherence rates per self-report.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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