Exercise Genes: Genomic Association With Exercise Reinforcement

Obesity Clinical Trial

— ExGenes  

Official title:

Exercise Genes: Genomic Association With Exercise Reinforcement

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02416882
• Other study ID #: GFHNRC405
• Status: Completed
• Phase: N/A
• Start date: April 2015
• Est. completion date: December 2015

Study information

• Verified date: July 2019
• Source: USDA Grand Forks Human Nutrition Research Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study tests whether different physical activity patterns are linked an individual's genes.

Description:

The investigators propose that an individual's genetics are one factor that may be associated with the motivating aspect or attractiveness of exercise and therefore the choice to exercise rather than be sedentary. They propose to study the association of the genomic signatures with the reinforcing (motivating) value of different types of exercise. This has never been investigated and may uncover underlying mechanisms that would help to understand individual differences in exercise motivation. The ultimate impact of this work is a greater number of Americans being physically active, meeting the United States Department of Agriculture (USDA) dietary guidelines for physical activity, and maintaining a healthy body weight. This study will be funded and undertaken at the Grand Forks Human Nutrition Research Center (GFHNRC). The purpose will be to assess genetic underpinnings of the motivating value of resistance and aerobic exercise, and to determine whether the motivating value of aerobic and resistance exercise are associated with usual participation in these modes of exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 88
• Est. completion date: December 2015
• Est. primary completion date: November 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• BMI within 18.5-35.0 kg/m2

• Healthy enough to exercise

• Active or inactive (not exercising at this time)

Exclusion Criteria:

• Taking any drugs that affect energy expenditure (e.g., thyroid, glucose-lowering drugs)

• Have gained or lost more than 5% of body weight over the past 6 months

• Use tobacco

• Pregnant or lactating or plan to become pregnant in the next 6 months

• Have any health conditions that prevent the individual from safely exercising (e.g., cardiovascular, liver, endocrine, or pulmonary diseases)

Related Conditions & MeSH terms

• Obesity
• Overweight
• Physical Activity

Intervention

Other:
• Aerobic Exercise
Subjects will sample and rate their liking of three cardiovascular machines (treadmill, cycle ergometer, elliptical step ergometer) to determine which one will be used during the test.
• Resistance Exercise
Subjects will sample and rate their liking of three different resistance training circuits (upper body, lower body, core) to determine which one will be used during the test.
• Sedentary Option
Subjects will rate their liking of three sedentary activities (reading magazines, playing puzzles, completing word games) as an alternative to exercise.

Locations

Country	Name	City	State
United States	USDA Grand Forks Human Nutrition Research Center	Grand Forks	North Dakota

Sponsors (1)

Lead Sponsor	Collaborator
USDA Grand Forks Human Nutrition Research Center

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Relative reinforcing value (RRV) of physical activity	RRV of physical activity will be assessed by evaluating the number of responses (mouse button presses) a subject is willing to complete to gain access to physical activity or a sedentary alternative.	Week 0 (Cross-sectional)
Primary	Preference for intense physical activity and tolerance for exercise discomfort	Preference for intense physical activity and tolerance for exercise discomfort will be assessed by self-report questionnaire responses.	Week 0 (Cross-sectional)
Primary	Genotypes of 23 small nucleotide polymorphisms (SNPs) previously identified to influence central dopamine release or uptake, reward, or physical activity	SNP genotyping will be performed on 3-5 ml samples of whole blood collected in ethylenediaminetetraacetic acid (EDTA)-containing tubes followed by allelic-discrimination analysis for the amplification and identification of each SNP.	Week 0 (Cross-sectional)