Obesity Clinical Trial
Official title:
Characterization of Obesity-related Cardiomyopathy Through Exploration of Human Atrial Trabeculae Contraction
The investigators aim to explore obese cardiomyopathy by studying contractile twitch force, sarcomere sensitivity to calcium and mitochondrial function in atrial myocardial samples of patients grouped according to their body mass index, i.e. normal weight, overweight and obese.
Obesity is associated with the development of heart failure, regardless of coronary artery
disease or other comorbidities.
Right atrial samples obtained from patients undergoing cardiac surgery and presenting no sign
of clinical cardiomyopathy will be grouped according to patient's body mass index. Atrial
trabeculae will be explored to dissect out the respective contribution of (i) sarcoplasmic
reticulum dysfunction (isometric twitch force contraction analysis), (ii) abnormal sarcomere
sensitivity to calcium assessed in permeabilized fibers and (iii) mitochondrial dysfunction
to intrinsec contractile dysfunction of myocardium in obese patients.
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