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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02377973
Other study ID # D209
Secondary ID H-3-2010-122
Status Completed
Phase N/A
First received February 27, 2015
Last updated March 3, 2015
Start date January 2011
Est. completion date February 2015

Study information

Verified date February 2015
Source University of Copenhagen
Contact n/a
Is FDA regulated No
Health authority Denmark: Danish Dataprotection AgencyDenmark: The Regional Committee on Biomedical Research Ethics
Study type Observational

Clinical Trial Summary

The overall aim is to provide a detailed description of growth, development and risk factors for later disease, especially obesity and metabolic disease in infants born by obese mothers and to compare them with a group of infants born by mothers without any restriction in prepregnancy BMI (SKOT I).


Description:

The SKOT II is a prospective cohort study that includes children of obese mothers with a body mass index over 30 kg/m2. These mothers were invited to SKOT II while participating in a randomised study at Hvidovre Hospital, Copenhagen. The families were invited to three examinations, when the children were 9, 18 and 36 months of age. A total of 184 children were included in 2010. The examinations and the collecting of data are designed in the same way as SKOT I, a study of healthy children born by non-obese mother. The examinations takes place at Department of Nutrition, Exercise and Sports, Frederiksberg, Denmark. Following data were collected during the examinations: Anthropometry (weight, height, age- and sex specific Z scores for body composition, triceps- and subscapularis skinfolds), background interview (e.g. infant feeding, household income, the parent's educational level, allergy and chronic diseases), blood pressure (systolic, diastolic and mean arterial pressure), faeces- and urine samples, blood samples (at 9 and 36 months of age), bio impedance (at 36 months of age), 4 day diet registration, general questionnaire (e.g. sleep, daycare, attendance and use of screen devices), psychomotor questionnaire (motoric development) and 7 day physical activity monitoring (at 36 months of age).


Recruitment information / eligibility

Status Completed
Enrollment 184
Est. completion date February 2015
Est. primary completion date February 2015
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 9 Months to 3 Years
Eligibility Inclusion Criteria:

- Healthy singletons born at term (week 37-43) with no disease that could influence food intake or growth. Born by obese mother (BMI = 30 kg/m2) Mothers participated in a intervention study at Hvidovre Hospital

Exclusion Criteria:

- Born preterm (before week 37) Non-Danish speaking parents. Chronic disease that is expected to influence growth or food intake.

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Locations

Country Name City State
Denmark Department of Human Nutrition, Faculty of Sciences, University of Copenhagen Frederiksberg

Sponsors (3)

Lead Sponsor Collaborator
University of Copenhagen Hvidovre University Hospital, Technical University of Denmark

Country where clinical trial is conducted

Denmark, 

Outcome

Type Measure Description Time frame Safety issue
Primary Change in anthropometric measurements in periods of early childhood Composite outcome consisting of body weight, height, body mass index (BMI) and BMI z-scores, waist-, upper arm- and head circumference, skinfold thickness measured at subscapularis and triceps. Compare the changes with those observed in SKOT-I (NCT02170428) 9, 18 and 36 months of age No
Primary Body composition in early childhood Body composition is measures by bio impedance. Fat mass, fat mass index (kg/m2), fat free mass index (kg/m2) are calculated. Compare the measurements with those observed in SKOT-I (NCT02170428) 36 months of age No
Primary Markers of Metabolic syndrome in early life Markers consisting of triglycerides, high lipoprotein (HDL) and glucose measured in plasma/serum, waist circumference and blood pressure. Compare the measurements with those observed in SKOT-I (NCT02170428) 9 and 36 months of age No
Primary Diet in periods of early life The diet is recorded using self-reported record questionnaire (7 days at 9 and 18 month, 4 days at 36 month). Compare diet with the SKOT-I cohort (NCT02170428) 9, 18 and 36 months of age No
Secondary Breastfeeding duration in infancy and early childhood Questionnaire used for assessment of exclusive and partially breastfeeding. Compare the duration with SKOT-I cohort (NCT02170428) 9, 18 and 36 months of age No
Secondary Insulin like growth factor at 9 and 36 months of age Insulin like growth factor-1 and insulin like growth factor binding protein-3 concentrations in plasma. Compare the measurements with those observed in SKOT-I (NCT02170428) 9 and 36 months of age No
Secondary Physical activity, sedentary behavior and sleep in early childhood Physical activity and sedentary behavior measured by ActiGrafph GT3X accelerometer, recording for 24 hours in 7 days at 36 months of age. Information on outdoor activity, sedentary behavior and night sleep are collected through questionnaires at 9, 18 and 36. months of age. Compare the measurements with those observed in SKOT-I (NCT02170428) 9, 18 and 36 months of age No
Secondary Vitamin D status in infancy 25-hydroxyvitamin D concentrations are analysed in blood samples at 9 months of age. Compare the measurements with those observed in SKOT-I (NCT02170428) 9 and 36 months of age No
Secondary Allergy and chronic diseases Assessment of diseases by questionnaires. Compare frequencies with those observed in SKOT-I (NCT02170428) 9 and 36 months of age No
Secondary Appetite hormones in infancy Leptin and adiponectin concentrations measured from blood samples. Compare the measurements with those observed in SKOT-I (NCT02170428) 9 and 36 months of age No
Secondary Change in gut microbiota Microbiota in the faeces analysed using polymerase chain reaction (PCR). Compare findings with SKOT-I (NCT02170428) : 9, 18 and 36 months of age No
Secondary Achievement of milestones Achievement of age-specific milestones by questionnaires; WHO questionnaires at 9 and 36 months of age and Ages & Stages Questionnaires (ASQ) at 36 months of age. Compare findings with SKOT-I (NCT02170428) 9 and 36 months of age No
Secondary Metabolomics in the urine Metabolomics analysed using urine samples. Compare findings with SKOT-I (NCT02170428) 9, 18 and 36 months of age No
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