Obesity Clinical Trial
Official title:
Activation of Brown Adipose Tissue in Lean and Obese Men
In this study the investigators aim to investigate whether the sympathetic stimulation of
BAT, as assessed with a 123I-metaiodobenzylguanidine single-photon emission computed
tomography computed tomography scan, differs between lean and obese individuals, as an
explanation for the diminished metabolic brown adipose tissue activity in obese subjects.
The investigators hypothesis is that sympathetic nervous system activity in the obese is
diminished as compared to their leaner counterparts as an explanation for the diminished
metabolic brown adipose tissue activity in the obese.
The sympathetic nervous system is the primary activator of Brown Adipose Tissue.
Obese humans are known to have less metabolically active brown adipose tissue as compared to
their leaner counterparts.
The reason for this diminished metabolic brown adipose tissue activity is unknown.
However, a lower sympathetic nervous system activation to brown adipose tissue in the obese
might explain a diminished metabolic brown adipose tissue.
Therefore, in this study, both the sympathetic nervous system activation to brown adipose
tissue and the metabolic activity will be measured in lean and obese subjects.
sympathetic nervous system activity will be measured using 123I-metaiodobenzylguanidine
single-photon emission computed tomography scans, metabolic activity will be measured using
18F- fluorodeoxyglucose positron emission tomography CT scans.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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