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Study to Investigate Benefits of Weight Loss in Young Adults and Adolescents

Obesity Clinical Trial

Official title:
Study to Investigate Benefits of Weight Loss in Yound Adults and Adolescents

Clinical Trial Summary

The purpose of this study is to investigate the changes in subcutaneous adipocyte size, number and gene expression after weight loss and to assess whether those changes contribute to decreases in ectopic fat accumulation and insulin resistance in women between ages of 16-32.

Clinical Trial Description

There are no studies in young women that have prospectively studied changes in fat cell size, gene expression and insulin sensitivity during the transition from overweight/obese to normal weight. Our preliminary data suggest that the presence of ectopic fat accumulation and insulin resistance in obese children could be considered an "early phase" in the development of T2DM. We hypothesize that a 10% weight loss will restore/improve insulin sensitivity. Furthermore, we speculate that the decrease in subcutaneous fat mass after weight loss is due to a decrease in mean adipocyte cell size, but not cell number. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01901978
Study type Interventional
Source Yale University
Contact
Status Completed
Phase N/A
Start date May 2011
Completion date August 2018
View Details
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