Obesity Clinical Trial
Official title:
The Effects of Differential Short Chain Fatty Acid Availability on Human Substrate and Energy Metabolism
Gut microbiota is being increasingly recognized as an important factor in fat distribution,
insulin sensitivity and glucose and lipid metabolism. Accordingly, the intestinal microbiota
could play an important role in the development of obesity and type 2 diabetes mellitus. The
role of gut-derived short-chain fatty acids (SCFA), the formation of which is enhanced by
microbial fermentation of fibre, is still controversial. At the present time, our
understanding of the effects of SCFA on human metabolism (in gut or systemically) is still
limited. The investigators hypothesize that the differential availability of SCFA impacts
human metabolism differently.
In this placebo controlled, double-blind, randomized crossover pilot study the investigators
will validate in overweight/obese healthy male volunteers whether rectal administration of
SCFA is a good model for studying the acute metabolic effects of SCFA. For this, it will be
investigated if site of administration (in distal or proximal colon) of SCFA differentially
affects parameters of substrate and energy metabolism and to test the duration of short-term
effects of SCFA administration.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)
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