Glypican4 and CTRP5 in Metabolic Syndrome and the Effect of Exercise on These Adipokines

Obesity Clinical Trial

Official title:

Effects of Exercise on Glypican4,CTRP3,5 and RBP4 Levels and Circulating Levels of These Adipokines in the Subjects With or Without Metabolic Syndrome

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01688622
• Other study ID #: KoreaSO_Exercise
• Status: Completed
• Phase: N/A
• First received: September 13, 2012
• Last updated: September 20, 2012
• Start date: July 2012
• Est. completion date: September 2012

Study information

• Verified date: September 2012
• Source: Korea University
• Contact: n/a
• Is FDA regulated: No
• Health authority: South Korea: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

Glypican4, CTRP3, CTRP5 are emerging novel adipokines mediating obesity and inflammation related disorders. RBP4 and adiponectin are well known important adipokines. Therefore, we examine the circulating levels of theses adipokines in the subjects with or without metabolic syndrome. Furthermore, we tried to clarify the effect of exercise on the circulating these adipokines.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: September 2012
• Est. primary completion date: September 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• Women between 30 and 60 years of age who had a body mass index (BMI) more than 25 kg/m2

• The subjects of metabolic syndrome and age, gender matched non metabolic syndrome among the participants of Korean SO Study (KSOS) study, which is an ongoing epidemiologic study supported by the Korea Science and Engineering Foundation

Exclusion Criteria:

• participants had a history of cardiovascular disease

• any type of diabetes

• stage 2 hypertension

• malignant disease, severe renal, or hepatic disease

• Subjects taking medications that might affect body weight or body composition

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Metabolic Syndrome
• Metabolic Syndrome X
• Obesity
• Syndrome

Intervention

Behavioral:
• 3months Exercise
training session consisting of a brief warm-up, followed by an approximately 45-min session of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (approximately 300 kcal/day) and a 20-min muscle strength train- ing programme (approximately 100 kcal/day), followed by a brief cool-down period.

Locations

Country	Name	City	State
Korea, Republic of	Korea University Guro Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Korea University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The changes of circulating glypican4 levels after 3 months exercise		baseline and 12weeks	No
Primary	The changes of circulating CTRP3 levels after 3 months exercise		baseline and 12weeks	No
Primary	The changes of circulating CTRP5 levels after 3 months exercise		baseline and 12weeks	No
Primary	The changes of circulating RBP4 levels after 3 months exercise		baseline and 12weeks	No
Primary	The changes of circulating adiponectin levels after 3 months exercise		baseline and 12weeks	No
Secondary	Circulating glypican4 levels in the subjects with or without metabolic syndrome		baseline	No
Secondary	Circulating CTRP3 levels in the subjects with or without metabolic syndrome		baseline	No
Secondary	Circulating CTRP5 levels in the subjects with or without metabolic syndrome		baseline	No
Secondary	Circulating RBP4 levels in the subjects with or without metabolic syndrome		baseline	No
Secondary	Circulating adiponectin levels in the subjects with or without metabolic syndrome		baseline	No