Acute Effects of Dietary Proteins on Postprandial Lipemia, Incretin Responses and Subclinical Inflammation in Obese Subjects

Obesity Clinical Trial

Official title:

Acute Effects of Dietary Proteins on Postprandial Lipemia, Incretin Responses and Subclinical Inflammation in Obese Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00863564
• Other study ID #: CERN-PPL-JHJ-5a
• Status: Completed
• Phase: N/A
• First received: March 17, 2009
• Last updated: November 9, 2009
• Start date: March 2009
• Est. completion date: October 2009

Study information

• Verified date: November 2009
• Source: Aarhus University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the effects of dietary protein on blood lipids and gut hormones after a fat-rich meal.

Hypothesis: Certain dietary proteins reduce the amount of fat circulating in the blood stream following a fat rich meal. The effect is dependant of both the quality and the quantity of protein ingested.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: October 2009
• Est. primary completion date: October 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 40 Years to 75 Years

Eligibility

Inclusion Criteria:

• BMI > 30 kg/m2 & < 45 kg/m2

Exclusion Criteria:

• Diabetes

• Lipid lowering drugs

• Liver-, Kidney- and/or Heart Disease

• Serious Hypertension (160/110)

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Atherosclerosis
• Hyperlipidemias
• Inflammation
• Obesity
• Postprandial Incretins
• Postprandial Lipemia

Intervention

Dietary Supplement:
• Caseine

• Cod

• Gluten

• Whey Isolate

Locations

Country	Name	City	State
Denmark	Department of Clinical Nutrion	Aarhus

Sponsors (3)

Lead Sponsor	Collaborator
Aarhus University Hospital	Nordic Centre of Excellence, The Danish Obesity Research Centre

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Triglyceride		0h- 2h- 4h- 6h- 8h postprandial	No
Secondary	Incretins		0h -1h -2h -4h -6h -8h Postprandial	No
Secondary	Inflammatory markers		0h- 1h- 2h- 4h- 6h- 8h postprandial	No