Obesity Clinical Trial
Official title:
Association of Genetic Variants in Obesity Genes to Resistance to Weight Loss and Susceptibility to Metabolic Syndrome in Morbidly Obese Patients: A Single Center, Blinded, Retrospective Clinical Study
The overall goal of this study is to determine whether variations in the perilipin, and
several other, genes would be a useful tool for physicians who are caring for morbidly obese
patients to guide therapy.
The main hypotheses to be tested is that sequence variations (polymorphisms) in the
perilipin gene and several other obesity-related genes are associated with resistance to
weight loss for obese individuals on energy restricted diets, potentially playing a role in
the development of obesity related complications.
The PRIMARY goal of this study is to investigate the association of perilipin gene
polymorphisms, with obese subjects who are "resistant" to weight loss in a defined program.
The SECONDARY goal of this study is to investigate if additional candidate obesity genes
that have previously been associated with obesity or energy metabolism show association with
resistance to weight loss in subjects on an energy restricted diet. Additionally, we would
like to investigate if any metabolic syndrome parameters, such as dyslipidemia or abnormal
fasting glucose are associated with perilipin or variations in other obesity-related genes.
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Observational Model: Cohort, Time Perspective: Retrospective
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