Obesity Clinical Trial
The purpose of this study is to evaluate the effect of rosiglitazone on bone metabolism and to assess the association between the changes in bone turnover parameters and plasma cytokine levels in postmenopausal diabetic women
Fifty-six obese, drug naive patients with type 2 diabetes mellitus were enrolled and
completed the study. Twenty-six healthy subjects matched for age and body mass index (BMI)
served as nondiabetic controls. All subjects were postmenopausal women with last menses at
least 2 years. After the baseline measurements, all subjects were instructed to follow a
weight-maintaining diet, based on ADA recommendations, and were also encouraged to walk or
to jog at least 30 min daily. Subsequently, 28 of the diabetic subjects were randomly
assigned to receive rosiglitazone (4 mg/day). Twenty-eight of diabetic subjects were on diet
alone. The randomization procedure was based on a random sequence.
All subjects had a complete clinical examination, anthropometric measurements, and
laboratory tests at baseline and at the end of the 12th week of the study. Laboratory
investigations included assessment of: (i) glycemic control (HbA1c, fasting plasma glucose
and insulin levels, and homeostasis model assessment (HOMA) index (22); (ii) serum bsALP and
active human osteocalcin concentration (OCL) as markers of bone formation; (iii) urine
deoxypyridinoline (DPD) as marker of bone resorption. Other non-specific bone markers
including serum total ALP activity, urinary calcium (Ca) and phosphate (PO4) concentrations
were also measured. Urine concentrations of DPD (nmol/L), Ca and PO4 (both in mmol/L) were
corrected for their respective urine creatinine (Cr) concentrations in mmol/L (Urine DPD/Cr,
Urine Ca/Cr and Urine PO4/Cr respectively). In addition, fasting blood samples were analyzed
for plasma cytokine levels including IL-1β, IL-6 and TNF-α, and for haptoglobin levels.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04101669 -
EndoBarrier System Pivotal Trial(Rev E v2)
|
N/A | |
| Recruiting |
NCT04243317 -
Feasibility of a Sleep Improvement Intervention for Weight Loss and Its Maintenance in Sleep Impaired Obese Adults
|
N/A | |
| Terminated |
NCT03772886 -
Reducing Cesarean Delivery Rate in Obese Patients Using the Peanut Ball
|
N/A | |
| Completed |
NCT03640442 -
Modified Ramped Position for Intubation of Obese Females.
|
N/A | |
| Completed |
NCT04506996 -
Monday-Focused Tailored Rapid Interactive Mobile Messaging for Weight Management 2
|
N/A | |
| Recruiting |
NCT06019832 -
Analysis of Stem and Non-Stem Tibial Component
|
N/A | |
| Active, not recruiting |
NCT05891834 -
Study of INV-202 in Patients With Obesity and Metabolic Syndrome
|
Phase 2 | |
| Active, not recruiting |
NCT05275959 -
Beijing (Peking)---Myopia and Obesity Comorbidity Intervention (BMOCI)
|
N/A | |
| Recruiting |
NCT04575194 -
Study of the Cardiometabolic Effects of Obesity Pharmacotherapy
|
Phase 4 | |
| Completed |
NCT04513769 -
Nutritious Eating With Soul at Rare Variety Cafe
|
N/A | |
| Withdrawn |
NCT03042897 -
Exercise and Diet Intervention in Promoting Weight Loss in Obese Patients With Stage I Endometrial Cancer
|
N/A | |
| Completed |
NCT03644524 -
Heat Therapy and Cardiometabolic Health in Obese Women
|
N/A | |
| Recruiting |
NCT05917873 -
Metabolic Effects of Four-week Lactate-ketone Ester Supplementation
|
N/A | |
| Active, not recruiting |
NCT04353258 -
Research Intervention to Support Healthy Eating and Exercise
|
N/A | |
| Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
| Recruiting |
NCT03227575 -
Effects of Brisk Walking and Regular Intensity Exercise Interventions on Glycemic Control
|
N/A | |
| Completed |
NCT01870947 -
Assisted Exercise in Obese Endometrial Cancer Patients
|
N/A | |
| Recruiting |
NCT06007404 -
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
|
||
| Recruiting |
NCT05972564 -
The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05371496 -
Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction
|
Phase 2 |