Food Rheology and Feeding in Lean and Obese Humans

Obesity Clinical Trial

Official title:

Study 1: Viscosity Study Study 2: Meal Timing Study Study 3:Chronic Fluid and Solid Food Intake in Lean and Overweight Individuals

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00260130
• Other study ID #: DK63185 (completed)
• Secondary ID: R01DK063185Study
• Status: Completed
• Phase: N/A
• First received: November 29, 2005
• Last updated: May 28, 2013
• Start date: February 2005
• Est. completion date: July 2009

Study information

• Verified date: May 2013
• Source: Purdue University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The 2010 National Health Objectives call for a reduction in the prevalence of obesity. The marked recent increase in overweight and obesity prevalence implicates behavioral factors in the etiology of the epidemic. The present proposal hypothesizes the trend is attributal, in part, to increasing consumption of energy-yeilding beverages since they are a significant and increasing source of dietarty energy and they elicit weaker appetitive and dietary responses than solid foods.

Description:

Three human studies are propsed to more fully characterized attributes of liquids and solids that may account for the differential appetitive responses they elicit, potential contributory mechanisms as well as the dietary implications of their consumption. Study 1 will contrast the acute effects of fluid and solid foods varying in macronutrient content on satiation, satiety and feeding. Study 2 will determine if the pattern of fluid and solid ingestion influences satiety and feeding by monitoring appetitive and dietary responses to energy and macronutrient matched fluid and solid loads ingested as meal components or between meal snacks. To better assess the clinical implications ofdiets incorpprating liquid or solid supplements. Study 3 will entail chronic ingestion of matched energy yeilding fluid or solid loads with concurrent measurement of appetite, dietary intake, energy expenditureand body weight/composition.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 34
• Est. completion date: July 2009
• Est. primary completion date: December 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• BMI 18-23 or 27-35

• weight stable

• constant habitual activity pattern

• low fruit/vegetable consumer

• non-restrained eater

Exclusion Criteria:

• diabetic

• taking medication known to influence appetite

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Diabetes
• Obesity
• Overweight

Intervention

Other:
• food in fluid form
dietary intake of fluid forms of vegetables
• food in solid form
dietary intake of solid forms of vegetables

Locations

Country	Name	City	State
United States	Purdue University	West Lafayette	Indiana

Sponsors (2)

Lead Sponsor	Collaborator
Purdue University	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	satiation and satiety on liquid verses solid foods with concurrent measurements of appetite, dietary intake, energy expenditure and body weight/composition.		8 weeks	No
Secondary	cephalic phase testing at week 8		30 minutes	No

External Links

•   Dr. Mattes Laboratory for Sensory and Ingestive Studies web site.