Effect of Exercise on Elevated C-reactive Protein Concentrations in Formerly Inactive Adults

Obesity Clinical Trial

Official title:

INFLAME: Inflammation and Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00113061
• Other study ID #: 180
• Secondary ID: R01HL075442
• Status: Completed
• Phase: N/A
• First received: June 3, 2005
• Last updated: July 28, 2016
• Start date: July 2004
• Est. completion date: June 2006

Study information

• Verified date: December 2007
• Source: National Heart, Lung, and Blood Institute (NHLBI)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the effect of exercise training on elevated C-reactive protein (CRP) concentrations, an indicator of inflammation, in initially inactive women and men.

Description:

BACKGROUND:

CRP, a marker of systemic inflammation, has been reported to be an independent predictor of cardiovascular disease in both women and men. Recently published data from cross-sectional analyses showed that CRP is inversely related to cardiorespiratory fitness, and that this association is independent of body mass index. Regular exercise may affect CRP levels, and can possibly be used as a means of reducing elevated CRP levels. Though there are a number of studies focusing on related topics, there are no published reports from randomized clinical trials on the effect of exercise training alone on CRP levels.

DESIGN NARRATIVE:

An estimated 200 individuals will be randomly assigned to either a no exercise control group or an exercise group. Exercising individuals will participate in 3 or 4 training sessions each week for 4 months, and will progress to a total energy expenditure of 16 kcal [kg(-1), week(-1)], which is an exercise dose at the upper end of current public health recommendations for physical activity. The target exercise intensity will be 50-70% of baseline volume of oxygen consumed (V02 max). VO2 max is the maximal rate of oxygen consumption during exercise, and is a measurement of fitness. The primary outcome measure will be plasma CRP concentration. Secondary outcomes will be changes in variables that are potential mechanisms through which regular exercise might reduce CRP. These variables include visceral adiposity, the cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), and heart rate variability as a measure of autonomic balance. Although the primary outcome is CRP level, this study will also contribute significantly to the limited body of literature examining the effect of exercise on the variables of visceral adiposity, cytokines, and heart rate variability.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 162
• Est. completion date: June 2006
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Physically inactive

• C-reactive protein level at least 2.0 mg/L but less than 10.0 mg/L upon study entry

• Body mass index between 18.5 kg/square meter and 40.0 kg/square meter as measured at study entry

• Does not smoke

• Total cholesterol at least 240 mg/dl with LDL-C at least 160 mg/dl OR LDL less than 190 mg/dl and Framingham less than 10%

• Triglyceride levels no higher than 300 mg/dl

• Fasting glucose level less than 126

• Systolic blood pressure less than 140 mm Hg and/or diastolic blood pressure less than 90 mm Hg as measured at study entry

• If taking an oral contraceptive, aspirin, ibuprofen, or other anti-inflammatory medications, must be on a stable dose for 6 months prior to study entry

• If taking a cholesterol medication, including statins, blood pressure medication (including ace inhibitors), or multi-vitamins, must be on a stable dose for 2 months prior to study entry

Exclusion Criteria:

• Using a beta blocker, hormone replacement therapy, or corticosteroids (except inhalers)

• Any rheumatologic, orthopedic, neurological, or autoimmune diseases, or seizure disorder

• Any significant cardiovascular disease or disorders including, but not limited to, stent or coronary artery bypass grafting

• Cardiac dysrhythmias including, but not limited to, left bundle branch block, atrial fibrillation, pacemaker, or automatic implantable cardioverter defibrillator

• Any surgery, broken bones, blood donation, or anaphylactic shock within 6 months of study entry

• Any sprain or strain, removal of wisdom teeth, or use of antibiotics within 3 months of study entry

• History of stroke or TIA

• History of cancer within at least 5 years of study entry

• Diabetes or glucose intolerance

• Planning on participating in any other research trials during the next year

• Currently pregnant

• Planning to becoming pregnant during the next year

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Cardiovascular Diseases
• Heart Diseases
• Obesity

Intervention

Procedure:
• Exercise

Locations

Country	Name	City	State
United States	Pennington Biomedical Research Center, LSU System	Baton Rouge	Louisiana

Sponsors (1)

Lead Sponsor	Collaborator
National Heart, Lung, and Blood Institute (NHLBI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Plasma CRP concentration (measured at Month 4)
Secondary	Changes in visceral adiposity, the cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), and heart rate variability (measured at Month 4)