Obesity Clinical Trial
Official title:
Examining the Relationship Between Acute Meal Intake and Inflammation in Children
NCT number | NCT03597542 |
Other study ID # | 17112 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | August 29, 2017 |
Est. completion date | February 2, 2018 |
Verified date | July 2018 |
Source | University of Illinois at Urbana-Champaign |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Recent evidence has shown that obese and overweight children exhibit states of chronic inflammation. In obese adults, a high carbohydrate meal induces an inflammatory response; however, the effects of a high carbohydrate meal on biomarkers of inflammation has not previously been examined in children. The purpose of this research project is to characterize the inflammatory response to a high carbohydrate versus a low carbohydrate meal in healthy weight, overweight, and obese children (age 7-17 years). After completing informed consent/assent, a Dual-energy X-ray Absorptiometry (DXA) scan, and baseline blood draw on experimental day 1, children will then return to the lab two times to ingest either a high or low carbohydrate beverage followed by post-meal blood collection for a total of 3 blood draws. Biomarkers of inflammation will be analyzed by flow cytometry and enzyme-linked immunosorbent assay (ELISA). Participants will be recruited through various studies through the Neurocognitive Kinesiology Lab/Body Composition and Nutritional Neuroscience Labs as well as through the local Champaign-Urbana community. Data from this project will provide a better understanding of the inflammatory response to different meals in healthy weight, overweight, and obese children.
Status | Completed |
Enrollment | 36 |
Est. completion date | February 2, 2018 |
Est. primary completion date | February 2, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 7 Years to 17 Years |
Eligibility |
Inclusion Criteria: • Between the ages of 7-17 Exclusion Criteria: - Younger than 7 years and older than 17 years - Presence of allergies to eggs and/or sugar substitutes - Presence of heart or respiratory disease - Presence of uncontrolled hypertension, diabetes - Use of anti-inflammatory medications - Presence of cancer or metabolic disease |
Country | Name | City | State |
---|---|---|---|
United States | University of Illinois at Urbana-Champaign | Urbana | Illinois |
Lead Sponsor | Collaborator |
---|---|
University of Illinois at Urbana-Champaign | Egg Nutrition Center |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Effects of egg or maltodextrin on inflammatory cytokines (Tumor necrosis factor-alpha, C-reactive protein, and Interleukin-6) | Will be used by determining any changes in inflammatory cytokines via enzyme-linked immunosorbent assay (ELISA) kits. | 3 weeks. | |
Secondary | Effects of egg or maltodextrin on inflammatory monocyte cells with and without expression of Toll-like receptor 4 and C-C Chemokine receptor-2. | Will be used by determining the cells per microliter of lysed whole blood. | 3 weeks. |
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