Clinical Trials Logo
NCT number NCT03188640
Study type Interventional
Source Linkoeping University
Contact
Status Completed
Phase N/A
Start date March 1, 2014
Completion date October 31, 2016

Clinical Trial Summary

The purpose of this study is to characterize the hormonal status in fertile women undergoing laparoscopic gastric bypass, pre- and postoperatively, and evaluate if there is a correlation between health-related quality of life and proposed hormone changes post-operatively.


Clinical Trial Description

Sex hormone levels in women with obesity are altered in comparison to normal weight subjects. Most previous studies have focused on questionnaire surveys, and on the emotional/psychological aspect of health-related quality of life (HRQoL). It has been shown that bariatric surgery can affect reproductive ability, but the relationship between hormonal changes and HRQoL has been sparsely studied.

Hormone balance is affected by fat allocation, insulin levels and liver function, and these factors are all influenced postoperatively. Also body image and altered body mass composition can influence sexuality in diverse ways.

This leads us to theorize that liver production of SHBG will change after surgery and impact serum concentrations of sex hormones. Normalized levels of testosterone and estrogen may lead to reduced symptoms of hyperandrogenism, restitution of normal menstrual cycles and changes in sexual functioning.

The focus of this study is to analyze sexual and health-related quality of life through questionnaire analyses, and to investigate levels of sex hormones pre- and postoperatively in women undergoing bariatric surgery. Results from questionnaire analyses and hormone data will be tested for possible correlations.


Study Design


Related Conditions & MeSH terms


See also
Status Clinical Trial Phase
 Recruiting NCT01870947 - Assisted Exercise in Obese Endometrial Cancer Patients N/A
 Completed NCT02235961 - Investigate Safety, Tolerability and Pharmacokinetics for Single Doses of NNC9204-0530 Alone and in Combination With Liraglutide in Overweight to Obese But Otherwise Healthy Male Subjects Phase 1
 Recruiting NCT00341406 - Fat Cell Size in Insulin Resistance N/A
 Recruiting NCT02918279 - Effect of Liraglutide for Weight Management in Pubertal Adolescent Subjects With Obesity Phase 3
 Completed NCT01222793 - Effects of Antipsychotics on Eating and Food Craving in People With Schizophrenia N/A
 Completed NCT01967563 - Study of the Effect of a Very-Low-Carbohydrate Diet on Energy Expenditure N/A
 Completed NCT00976105 - Effects of Repeat Dosing of GSK1521498 Phase 1
 Completed NCT00535600 - Effects of Bariatric Surgery on Insulin N/A
 Not yet recruiting NCT03104205 - MOWI Home-Based Pilot N/A
 Recruiting NCT03104192 - MOWI Research Pilot N/A
 Not yet recruiting NCT02924636 - Electronic-personalized Program for Obesity in Pregnancy to Improve Delivery N/A
 Suspended NCT01387126 - Effects of a High Viscosity Dietary Fibre, as Part of a Medically Supervised Weight Management Program Phase 3
 Not yet recruiting NCT02621086 - Cellodextrin Tolerability Study N/A
 Not yet recruiting NCT02957539 - Financial vs. Non-Financial Rewards for Weight Loss and Weight Maintenance N/A
 Recruiting NCT03006328 - The GEM (Goals for Eating and Moving) Study N/A
 Recruiting NCT03031951 - Lifestyle Intervention Program for Former Elite Athletes N/A
 Recruiting NCT02934113 - "Working for You" Workplace Obesity Intervention N/A
 Recruiting NCT02988999 - Efficacy of D-allulose on Weight and Fat Loss and Insulin Resistance in Non-diabetic Obese Subjects N/A
 Recruiting NCT02899390 - Diabetes Prevention Program in Adults of the Yaqui Tribe of Hermosillo, Sonora at Risk of Diabetes N/A
 Recruiting NCT03097237 - High Fiber Rye Foods for Weight and Body Fat Reduction N/A