Myocardial Ischemia Clinical Trial
Official title:
Comparative Cohort Study on the Outcome of Patients With Normal and Reduced Acetylsalicylic Acid Responsiveness Undergoing Coronary Artery Bypass Surgery
In patients undergoing coronary artery bypass graft (CAGB) surgery, aspirin is commonly
prescribed to prevent graft thrombosis and myocardial ischemia. However, there are still a
significant number of grafts occluding in the postoperative period. This is partly
attributed to reduced aspirin responsiveness, also called "aspirin resistance". At the
moment, no standardized definition or laboratory test is available to quantify "aspirin
resistance", and strong platelet reactivity in laboratory tests is not necessarily
associated with increased thrombotic events. However, there is increasing evidence that
reduced aspirin responsiveness in platelet function analyzers is associated with adverse
long-term outcome and higher incidence of major adverse events in patients with stable
coronary artery disease and in patients undergoing percutaneous coronary intervention. In
patients undergoing coronary artery bypass graft surgery, the predictive value of a
laboratory finding of reduced aspirin responsiveness remains unclear.
Therefore, the aim of this study is to prospectively evaluate whether the pre- and/or
postoperative laboratory finding of reduced aspirin responsiveness defined by MultiplateTM
platelet function analyzer is associated with higher incidences of adverse outcome after 30
days and 12 months in patients undergoing CABG surgery.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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