Myocardial Ischemia Clinical Trial
Official title:
Glutamate Infusion in Hypertrophied Ventricle After Aortic Valve Replacement - a Randomized Trial
Purpose: The effect of intravenous glutamate infusion on myocardial diastolic function and
overall hemodynamics were studied in patients undergoing elective aortic valve replacement
with severe aortic stenosis and associated left ventricular hypertrophy .
Methods: 25 patients will be included in this double-blind randomized placebo-controlled
study. Glutamate was administered intravenously immediately after aortic cross-clamp
release. The patients receive either a low dose of 30mg kg-1 h-1 (LG-group) or high dose of
60 mg kg-1 h-1 (HG-group) or placebo (P-group) at a rate of 3.3ml kg-1h-1 for 2h.
Transesophageal echocardiography (TEE) is used to measure diastolic and systolic ventricular
function before sternotomy (T0), and 2h (T2), 3h (T3) and 6h (T4) after release of cross
clamp. Additionally routine hemodynamic parameters are measured intraoperatively.
n/a
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Primary Purpose: Treatment
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