Multiple Myeloma Clinical Trial
Official title:
A Phase 1 Study of Chimeric Antigen Receptor Modified T-cells Targeting NKG2D-Ligands in Patients With Acute Myeloid Leukemia (AML)/Advanced Myelodysplastic Syndrome (MDS-RAEB) and Multiple Myeloma.
This Phase I clinical trial is evaluating chimeric-antigen receptor (CAR) T-cells (CM-CS1 T cells) which recognize NKG2D-ligands on the surface of cancer cells. This study evaluates the safety and feasibility of administering a single intravenous dose of CM-CS1 CAR T-cells to patients with AML, MDS-RAEB and Multiple Myeloma.
This is a study for patients with AML or MDS-RAEB that is not in remission and for which
there are no reasonable standard treatment options and for patients with relapsed/refractory
multiple myeloma with progressive disease.
In this study, the participant's white blood cells (T-cells) will be collected and modified
such that the T-cells are able to recognize specific molecules (called NKG2D-ligands), that
are expressed on the surface of cancer cells in these diseases. This modification is a
genetic change to the T-cells. The modified T cells, called CM-CS1 T-cells, are then given
back to the participant by a single intravenous infusion. In this study, participants will
not receive any chemotherapy prior to infusion of the CM-CS1 T-cells.
The study will evaluate whether it is safe and feasible to administer CM-CS1 T-cells to
participants with AML/MDS-RAEB and multiple myeloma. It will also evaluate whether the CM-CS1
T-cells have a beneficial effect against the cancer cells. Another goal of the study is to
learn more about the persistence and function of the CM-CS1 T-cells in the body.
Participants will be followed very closely during the first month after infusion. They are
required to remain within 50 miles of Brigham and Women's Hospital (Boston, MA) for 10 days
after the infusion and will be followed three times per week for the first 21 days and at day
28. Subsequently, participants will be followed monthly until 6 months after infusion, every
3 months until 15 months after infusion and at 24 months after infusion. Because this study
involves gene transfer, participants will be followed yearly for up to 15 years.
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