Pulmonary Embolism and Thrombosis Clinical Trial
Official title:
Lung Perfusion Measured With Dual-Energy CT (DECT) in Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH): Comparative Study With Right Heart Catheterization and Ventilation/Perfusion Scintigraphy (V/Q)
A comparative, observational, cross-sectional and prolective diagnostic test study, including
patients that have had a right heart catheterization and were referred for a CT pulmonary
angiography as part of their imaging workup protocol for pulmonary hypertension.
Dual-energy computed tomography (DECT) pulmonary angiography was performed on each patient to
obtain perfusion maps and do a quantitative analysis. Segments with and without perfusion
defects according to significant differences in the quantitative values, were defined as
compatible or not with chronic thromboembolism.
To assess the accuracy of the method and evaluate its performance, these results were
compared with the sole results from the right heart catheterization, known to be the gold
standard diagnostic tool.
a comparative, observational, cross-sectional and prolective diagnostic test study is
conducted, including consecutive patients from the pulmonary hypertension clinic at our
institution, from March 2017 to October 2018. Patients that have had a right heart
catheterization and were referred for a CT pulmonary angiography as part of their imaging
workup protocol. (The minimum sample size calculated is 26 patients).
DECT pulmonary angiography (256-slice and double-source CT scanner) was performed on each
patient. Obtaining perfusion maps and doing a quantitative analysis by circular regions of
interest (ROI) and iodine-related attenuation values (IRA) on each lung segment. Then,
according to the finding in right heart catheterization, a comparison will be made between to
groups: segments with and without perfusion defects, in order to find significant differences
in the quantitative.
To assess the accuracy of the method and evaluate its performance, these results were later
compared with the sole results from the right heart catheterization.
ROC curves were plotted to extract possible decision thresholds of the IRA values to classify
perfusion as normal or deficient with this technique.
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