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Genetic Variants and Oxidative Stress as Links Between Periodontitis and Metabolic Syndrome

Metabolic Syndrome Clinical Trial

Official title:
Genetic Variants and Oxidative Stress as Links Between Periodontitis and Metabolic Syndrome

Clinical Trial Summary

The aim of this study is to investigate the systemic impact of periodontitis in patients with Metabolic Syndrome, by assessing measures of sub-clinical atherosclerosis and cardiovascular risk, microbial factors and host genetic variants, and to study the possible effect of mediators of inflammation and oxidative stress as links between the two conditions.

Clinical Trial Description

This is a cross-sectional study. 102 patients with metabolic syndrome will be recruited and will have periodontal and dental examination for diagnosis of caries and periodontal diseases. They will undergo blood, saliva, GCF and subgingival plaque sampling and a series of tests on cardiovascular disease, including measures of pulse-wave velocity,carotid intima-media thickness and echocardiography assessment. Statistical analysis will assess associations between dental diagnoses and metabolic, cardiovascular, inflammatory, genetic, microbial and cardiovascular risk outcomes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03297749
Study type Observational
Source University College, London
Contact
Status Active, not recruiting
Phase N/A
Start date July 1, 2015
Completion date December 31, 2020
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