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Metabolic Acidosis clinical trials

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NCT ID: NCT05842369 Recruiting - Metabolic Acidosis Clinical Trials

ADVOS® Versus CVVHD in Metabolic or Mixed Acidosis

Start date: April 17, 2023
Phase: N/A
Study type: Interventional

The aim of the study is to investigate the effects of ADVOS® therapy in critically ill patients with acute kidney injury, necessity of renal replacement therapy and acidosis. The investigators aim at assessing superiority of ADVOS® versus CVVHD for the primary outcome hours alive with normal pH (arterial pH ≤ 7,35) until 24 hours in a modified intention-to-treat analysis (mITT: replacement if dropped out before treatment start).

NCT ID: NCT05784389 Recruiting - Kidney Diseases Clinical Trials

Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5

REMA-CKD
Start date: March 27, 2023
Phase: N/A
Study type: Interventional

This clinical trial aims to investigate and test the effect of an acid/base diet in chronic kidney disease (CKD) patients, CKD stage 4 and 5. The trial is guided by the hypothesis that an acid/base diet will reduce the degree of acidosis and simultaneously reduce the need for bicarbonate supplements.

NCT ID: NCT05697770 Recruiting - Shock Clinical Trials

SODium BICarbonate for Metabolic Acidosis in the ICU

SODa-BIC
Start date: April 26, 2023
Phase: Phase 3
Study type: Interventional

This trial aims to assess if, among adults in the ICU with metabolic acidosis, an infusion of sodium bicarbonate diluted in 5% dextrose, compared with an infusion of 5% dextrose, reduces Major Adverse Kidney Events within 30 days of randomization.

NCT ID: NCT05582824 Recruiting - Metabolism Clinical Trials

Lactate Metabolism in the Hypoperfused Critically Ill

Start date: September 15, 2022
Phase:
Study type: Observational

Investigating lactate metabolism in critically ill patients whom are hypoperfused by preforming metabolomics via liquid chromatography-mass spectrometry.

NCT ID: NCT05259202 Recruiting - Metabolic Acidosis Clinical Trials

Value of Fetal Scalp Lactate Sampling During Labour in Cases of Abnormal Fetal Heart Rate

Start date: February 1, 2022
Phase:
Study type: Observational

ST-analysis of the foetal ECG (STAN®) is another second line technique for intrapartum foetal monitoring. Combining ST-analysis with standard CTG interpretation aims to identify hypoxic foetuses more accurately than CTG alone. The STAN® method identifies changes in the ST-interval of the foetal ECG that occur in the presence of foetalcentral hypoxia The aim of this studie is to investigate if the foetal lactate blood sampling is still useful when STAN® monitoring is already being used as a second line technique for intrapartum foetal monitoring if the fetal heart rate is abnormal without a significant ST event Nowadays in the Montpellier hospital's protocol, the investigators have to check the value of lactate sampling in case of le STAN doesn't detect an ST event. So this studie can change the Montpellier hospital's protocol and avoid useless fetal blood sampling

NCT ID: NCT05113641 Recruiting - Clinical trials for Chronic Kidney Diseases

Reducing Dietary Acid With Food Versus Oral Alkali in People With Chronic Kidney Disease (ReDACKD)

ReDACKD
Start date: August 4, 2023
Phase: Phase 1
Study type: Interventional

Metabolic acidosis is a common problem that occurs with worsening chronic kidney disease. Dietary acid can build up when the kidneys are not working well. This can be associated with a higher risk of worsening kidney function and death. The usual treatment is a medication called sodium bicarbonate which works to balance the acids in the body. The medication however often does not work and causes side effects. Consumption of alkalizing fruit and vegetables may work as a treatment for metabolic acidosis. This trial is being done to see if fruit and vegetables, provided via home delivery, can become a viable management for metabolic acidosis in patients with chronic kidney disease.

NCT ID: NCT05005793 Recruiting - Vascular Diseases Clinical Trials

Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients

Start date: December 1, 2021
Phase: Phase 4
Study type: Interventional

Lower serum bicarbonate levels, even within the normal laboratory range, in kidney transplant recipients (KTRs) are associated with an increased risk of graft loss, cardiovascular events and mortality. Because acid retention is common in KTRs, it is plausible that alkali therapy in KTRs may also result in improved vascular and graft function. The investigators will perform a randomized, double-blinded, placebo-controlled, 12 month study in 120 KTRs to examine the effect of sodium bicarbonate therapy on surrogate markers of CVD and graft function. The overall hypothesis is that treatment with bicarbonate will improve indicators of vascular and graft function in KTRs by decreasing complement activation.

NCT ID: NCT04984226 Recruiting - Diabetes Clinical Trials

Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

Senergy-CKD
Start date: September 8, 2023
Phase: Phase 2
Study type: Interventional

Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in vivo tools to study the pathophysiology of poor physical endurance in a clinical trial treating metabolic acidosis among persons living with chronic kidney disease.

NCT ID: NCT03897101 Recruiting - Inflammation Clinical Trials

Inflammation and Metabolic Acidosis at Birth (AGAIN: AutophaGy AcIdosis Newborn)

AGAIN
Start date: March 1, 2019
Phase:
Study type: Observational [Patient Registry]

Protection of brain development is a major aim in the Neonatal Intensive Care Unit. Neonatal encephalopathy (NE) occurs in 1.8 to 7.7 infants per 1000 births. Over the last six years, several randomized control trials have demonstrated that therapeutic hypothermia reduces the rate of death or disability at 18 months of age among infants who survived. However, the neurodevelopmental outcome in milder NE not treated with hypothermia remains unclear. A multicenter prospective observational study will be conducted to determine biological changes of mild neonatal encephalopathy who are not recruited for therapeutic hypothermia .

NCT ID: NCT01860001 Recruiting - Metabolic Acidosis Clinical Trials

Incidence of Postoperative Ketosis and Metabolic Acidosis

POKACID
Start date: October 2012
Phase: N/A
Study type: Observational

The aim of this study is to define the incidence and nature of acidosis after major surgery using Figge's equations to directly measure acidosis. This study will also aim to compare the ability of indirect measures (base deficit, anion gap,corrected anion gap and lactate) to identify the presence of tissue acids in this population. The incidence of postoperative ketoacidosis as a contributor to tissue acidosis will be assessed through the use of point of care urinalysis.