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Exercise Training and Thrombotic Risk in Post-menopausal Women — TIME  

Menopause Clinical Trial

Official title:
Susceptibility to Thrombosis in Post-menopausal Women- Influence of Exercise Training

Clinical Trial Summary

At menopausal transition, the risk of cardiovascular diseases increases. This is partly due to aging, but largely also the loss of estrogen, which has many positive effects on the circulation and protects against cardiovascular diseases. It has been suggested that the loss of estrogen may have a negative impact on the otherwise well-documented health promoting effects of exercise training, and that the time after menopause may be crucial for the effect of exercise training on the vascular function, and therefore also for the risk of thrombosis. Literature regarding the effect of exercise training on the risk of thrombosis is limited, and especially in women. The purpose of the present study is to investigate whether the same effects of exercise training in relation to thrombosis is achieved if the exercise is initiated early compared to late after menopause. The aim is to provide knowledge-based recommendations regarding exercise. Teams sports will be used as the training intervention, because team sports benefits physical health and also includes a social element.

Clinical Trial Description

Part of the novelty of this project is to link functional measurements of cardiovascular health at whole body level to cell studies. Cells will be isolated from muscle samples obtained from the post-menopausal women before and after the training intervention. This will enhance the understanding of the changes that occur after prolonged loss of estrogen on thrombotic risk and vascular function, and whether exercise training can alter these parameters. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04596501
Study type Interventional
Source University of Copenhagen
Contact
Status Active, not recruiting
Phase N/A
Start date March 1, 2021
Completion date December 31, 2023
View Details
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