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Marijuana Abuse clinical trials

View clinical trials related to Marijuana Abuse.

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NCT ID: NCT03629106 Withdrawn - Bipolar Disorder Clinical Trials

Effects of Cannabis Abstinence on Symptomology and Cognition in Bipolar Disorder

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

The objective of this study is to assess the changes in symptoms and cognition that occur after a 28-day abstinence period in patients with comorbid Cannabis Use Disorder (CUD) and Bipolar (Type I or II) disorder. Stabilized bipolar patients (N=52) with CUD will be randomly assigned to one of two groups: 1) A contingent reinforcement (CR) group (n=26); 2) a non-contingent reinforcement (NCR) group (n=26). The study will include a total of 8 visits to the CAMH Russell site (screening, training, baselines, week 1-4, follow-up). Participants should be between the ages of 18-60, meet criteria for CUD (moderate to severe), meet criteria for Bipolar Disorder, be on a stable dose of mood stabilizing medication(s), and be non-treatment seeking cannabis user. The visits will take up a total of approximately 22.5 hours with compensation for time provided for both groups. These visits will involve multiple clinical, substance use, and cognitive assessments. Abstinence will be maintained by weekly behavioural coaching sessions and contingency reinforcement for the CR group.

NCT ID: NCT03245658 Withdrawn - Mortality Clinical Trials

The Effect of Cannabis in Pancreatic Cancer

Start date: October 6, 2017
Phase: Phase 2
Study type: Interventional

Cannabinoids are known to increase appetite, but THC components have psychogenic properties too. CBD is the main component in the plant, and have only minimal psychogenic effects. The aim was to test the appetite stimulating effects of CBD in patients with pancreatic cancer in palliative treatment.

NCT ID: NCT02059083 Withdrawn - Clinical trials for Adolescent Cannabis Use Disorder

Biofeedback for Adolescent Cannabis Use Disorder

Start date: September 2014
Phase: Phase 1/Phase 2
Study type: Interventional

The aims of this study are: 1) to estimate the effect size of HRV biofeedback for stress in adolescents undergoing cognitive behavioral therapy (CBT) for cannabis use disorder (primary outcome: Perceived Stress Scale) and 2) to estimate the effect size of HRV biofeedback for cannabis use in adolescents undergoing CBT for cannabis use disorder (primary outcome: number of days used cannabis in the past 30 days).

NCT ID: NCT01969474 Withdrawn - Tinnitus Clinical Trials

Effectiveness of Cannabis in the Treatment of Tinnitus Patients

Start date: December 2013
Phase: Phase 1
Study type: Interventional

The hypothesis of the study is that the use of Cannabis will attenuate the tinnitus level as experienced by the patients.

NCT ID: NCT01784627 Withdrawn - Nicotine Dependence Clinical Trials

Trial of Computerized SBI to Reduce Teen Alcohol Use

Start date: January 2015
Phase: Phase 1
Study type: Interventional

The goal of this project is to test the effectiveness of a computer-facilitated alcohol screening and brief intervention (c-ASBI) system for 12- to 18-year-old primary care patients in a multi-site, randomized comparative effectiveness trial. The investigators hypothesize that, among 12- to 18-year olds patients coming for annual well-care, those receiving c-ASBI will have lower rates of any alcohol use at 3-, 6-, and 12-month follow-ups compared to Treatment As Usual (TAU).

NCT ID: NCT01031290 Withdrawn - Cannabis Use Clinical Trials

Pilot Study Repetitive Transcranial Magnetic Stimulation (rTMS) in Cannabis Craving

Start date: August 19, 2009
Phase: Phase 1
Study type: Interventional

Background: - Cannabis, also known as marijuana, is a commonly abused drug. There is no approved medication to treat cannabis addiction. The desire to use cannabis often increases when seeing others use it or seeing pictures of it. Researchers are interested in determining which parts of the brain are active when looking at pictures associated with cannabis. - Repetitive transcranial magnetic stimulation (rTMS) uses magnetic pulses to stimulate the brain. These pulses can change activity in parts of the brain. Researchers are interested in determining whether rTMS can decrease activity in the parts of the brain that respond to cannabis, and thereby lessen cravings for cannabis. Objectives: - To determine whether transcranial magnetic stimulation can lower craving for cannabis when people who use cannabis are shown images that increase craving. Eligibility: - Individuals 18 years of age and older who are physically healthy and currently use cannabis (at least 3 times weekly for the past 2 years). Design: - The study will involve eight visits over 3 weeks, with each visit lasting 1 to 2 hours. - Participants will have an initial assessment about cannabis use and provide blood and urine samples before beginning the study. - Participants will have three magnetic resonance imaging (MRI) brain scans. The first MRI scan will look at the structure of the brain at rest. During the other two scans, participants will look at images related to and not related to cannabis use. - The rTMS sessions (with either actual TMS or inactive [sham] TMS) will be held daily for 5 consecutive days. During these testing visits, researchers will ask questions related to drug use and craving, and collect urine and breath samples for further study. - Participants will have two follow-up visits, 1 week and 2 weeks after the rTMS sessions, to evaluate memory and mood, and one final MRI brain scan at the end of the study.