Major Depressive Disorder (MDD) Clinical Trial
Official title:
The Effects of Dopamine on Reward Processing
The purpose of this study is to evaluate the effects of a single low dose of the D2/D3
antagonist amisulpride on reward processing. More generally, this study will test the role of
dopamine (a naturally occurring brain chemical) in depression.
Hypotheses:
Administration of a single low dose of the D2/D3 antagonist amisulpride will (1) improve
performance in a behavioral task assessing learning from feedback and (2) boost activation in
reward-related brain regions.
Through an integration of a functional magnetic resonance imaging (fMRI) approach coupled
with a pharmacological challenge, the goal of the current study will be to investigate the
role of dopamine in MDD. Participants in this research will include 36 MDD subjects and 36
demographically matched healthy participants recruited from the community by Dr. Pizzagalli's
laboratory at McLean Hospital's Center for Depression, Anxiety and Stress Research. This
study will include two sessions:
- The first session will involve a diagnostic interview, and a series of questionnaires
and assessments.
- The second session will take place at the McLean Hospital's Neuroimaging Center, and
include the administration of a low-dose of amisulpride (50 mg capsule) or placebo,
followed by an fMRI brain scan and administration of two behavioral tasks.
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