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Major Depression clinical trials

View clinical trials related to Major Depression.

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NCT ID: NCT03484754 Active, not recruiting - Major Depression Clinical Trials

Infiltrations of OnaBotulinum Toxin A in Resistant Depression: Comparison of Two Facial Injection Sites.

OnaDEP
Start date: April 1, 2018
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate in adult subjects with resistant depression the effect of an injection of botulinum toxin in the corrugator and procerus muscles, in comparison to the infiltration of the crow's feet area, in addition to the current antidepressant treatment.

NCT ID: NCT03472638 Active, not recruiting - Major Depression Clinical Trials

Dorsomedial rTMS For Depression In Borderline Personality Disorder

rTMS
Start date: July 2016
Phase: N/A
Study type: Interventional

This randomized trial with a crossover design will examine the efficacy of rTMS targeting the dorsomedial prefrontal cortex as a treatment for medication-resistant major depression in patients meeting diagnostic criteria for borderline personality disorder.

NCT ID: NCT02622633 Active, not recruiting - Major Depression Clinical Trials

Epidural Stimulation for Resistant Depression Treatment

Start date: April 2016
Phase: Phase 2
Study type: Interventional

This study aims to analyze the effectiveness and feasibility of using an implantable system that provides epidural electrical stimulation directly to the left prefrontal dorsolateral cortex (Brodmann area 9/46) in patients with chronic and refractory Depressive Disorder Major.

NCT ID: NCT02441387 Active, not recruiting - Major Depression Clinical Trials

Predictors of the Outcome of Late Life Depression

Start date: April 2015
Phase:
Study type: Observational [Patient Registry]

Predictors of response to pharmacological treatment of major depressive disorder will be investigated. One hundred and twenty patients will be included in a naturalistic clinical trial. Psychopathology, personality traits, cognitive performance, brain structural changes and genetic polymorphisms will be evaluated. Patients will be followed for 18 months with a pharmacological treatment algorithm and will be evaluated monthly until 6th month and every 3 months, up to 18 months. Psychoeducation will be offered to patients who did not remit until 3 months of pharmacological tretment.

NCT ID: NCT02434393 Active, not recruiting - Major Depression Clinical Trials

Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project

ADNI-D
Start date: March 4, 2015
Phase:
Study type: Observational

The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study. One hundred and twenty (120) subjects who meet criteria for Major Depression or LLD will be enrolled for a period of 30 months. Data from an additional 300 non-depressed subjects will be used from ADNI studies for comparison. Depression history, symptom severity and health information will be collected at the initial psychiatric visit to determine eligibility. A 3 Tesla (3T) Magnetic resonance imaging (MRI) scan and florbetapir (18F-AV-45) amyloid imaging will be conducted at the ADNI clinic site visits. Collection of plasma and serum for biomarkers, clinical assessments and cognitive assessments will be conducted at two time points. Blood samples will also be collected for genetic analysis.

NCT ID: NCT01749124 Active, not recruiting - Schizophrenia Clinical Trials

My Coach Connect: An Automated Telephone-based Reporting System for Patients With Mental Illness

MCC
Start date: December 2012
Phase: N/A
Study type: Interventional

This is a pilot study for a novel, automated telephone system called "My Coach Connect". The purpose of the study is to evaluate the feasibility and effectiveness of this telephone tool while engaging clients and providers in discussion groups and surveys to better understand how this tool impacts the care provided and their overall experience in healthcare.

NCT ID: NCT01556971 Active, not recruiting - Major Depression Clinical Trials

Efficacy Study of Botox for Depression

Start date: February 2011
Phase: Phase 4
Study type: Interventional

The objective of this proposed study is to obtain data on the efficacy of Botox in reducing symptoms of MDD in male and female patients between the ages of 18 and 65 years old. The secondary object is to visually assess each patient's frown before and after the Botox injection to determine if there is a correlation between changes in the frown and changes in mood. The patients will be photographed at screening, visit 2 and 3. Their frown lines will be compared to determine if there is a visible improvement in the frown lines corresponding to an improvement in the efficacy rating scores.

NCT ID: NCT01230047 Active, not recruiting - Depression Clinical Trials

Mindfulness and Lifestyle Interventions for Depression and Anxiety: A Pilot Study

Start date: October 2010
Phase: N/A
Study type: Interventional

This is a quasi-experimental evaluation of psychoeducational course focusing on mindfulness and lifestyle changes for depression and anxiety; clients in active treatment group are compared to those in a treatment-as-usual wait-list control group. The primary hypothesis is that the psychoeducational course will result in lower levels of depression and anxiety as compared to the wait-listed treatment-as-usual comparison group.

NCT ID: NCT00627029 Active, not recruiting - Cancer Clinical Trials

Evaluation of Programs of Coordinated Care and Disease Management

Coca
Start date: September 2000
Phase: N/A
Study type: Interventional

This is a Congressionally mandated study. In the original study, 16 demonstration programs provided care coordination services to beneficiaries with chronic illness in Medicare's fee-for-service program. A five-year CMS-funded study tested whether the programs can improve patients' use of medical services, improve patients' outcomes and satisfaction with care, and reduce Medicare costs. The study also assessed physicians' satisfaction with the programs. In 2008 Congress extended the project for two of the original programs--Mercy Medical Center - North Iowa and Health Quality Partners in Pennsylvania--and they will enroll Medicare beneficiaries and provide care coordination services into the spring of 2010.

NCT ID: NCT00605358 Active, not recruiting - Major Depression Clinical Trials

Increasing Use of Mental Health Services

Open Door
Start date: August 2007
Phase: N/A
Study type: Interventional

The purpose of this study is to test the effectiveness of Open Door (previously known as the Treatment Initiation Program [TIP]), a brief psychosocial intervention to address the psychological barriers to care and improve the use of mental health services by depressed community elderly. The intervention is designed to help the older adult identify the barriers, problem-solve to find solutions and mobilize the motivation to seek help. Open Door was developed to work collaboratively with an older adult who is depressed to improve access and adherence to mental health treatment.