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Macular Degeneration clinical trials

View clinical trials related to Macular Degeneration.

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NCT ID: NCT03918590 Enrolling by invitation - Clinical trials for Diabetic Macular Edema

Post Intravitreal Injection Topical NSAID vs. Patching

Start date: December 3, 2018
Phase: Phase 4
Study type: Interventional

A prospective randomized trial, to evaluate post-injection comfort measures comparing topical NSAID (nepafenac 0.3% suspension) and patching.

NCT ID: NCT03882606 Enrolling by invitation - Clinical trials for Age-Related Macular Degeneration

Implantation of SML in Patients With Dry Age-related Macular Degeneration and Myopic Maculopathy

Start date: May 22, 2019
Phase: N/A
Study type: Interventional

Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in developed countries among people over 50 years of age. Myopic maculopathy is also an important cause of irreversible vision loss. Reduced near visual acuity is still a major problem with all forms of AMD and myopic maculopathy. Various intraocular lenses for near vision (IOLs) or telescopic systems have been described but are not widely accepted and almost all solutions require phakic status of the eye and are implanted during cataract surgery. Therefore, these devices are not appropriated for pseudophakic AMD and myopic maculopathy patients. Scharioth Macula Lens (SML, Medicontur) is a magnifying intraocular lens for pseudophakic patients implanted in the ciliary sulcus in one eye of each patient. The implant has a bifocal optic, with a central 1.5mm diameter optical zone equivalent to +10D add and a peripheral zone optically neutral. The implantation of the add-on SML can improve the near visual acuity of pseudophakic patients with AMD and myopic maculopathy without impairing their distance visual acuity. The principal objective is to compare the near visual acuity, the far visual acuity and the self-reported vision health status before and after the SML implantation.

NCT ID: NCT03772938 Enrolling by invitation - Clinical trials for Retinitis Pigmentosa

Stem Cells Therapy in Degenerative Diseases of the Retina

Start date: December 13, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to test the safety and effectiveness of an autologous bone marrow-derived stem/progenitor cells administered intravitreously in the subjects with degenerative diseases of the retina.

NCT ID: NCT03760055 Enrolling by invitation - Glaucoma Clinical Trials

Assessment of Visual Function With a Portable Brain-computer Interface

Start date: February 11, 2019
Phase:
Study type: Observational

1. The purpose of this study is to evaluate the nGoggle's accuracy and repeatability in detecting visual function loss. In addition, the ability to stage glaucomatous damage and investigate the relationship between nGoggle metrics and neural damage in glaucoma will also be evaluated. 2. Longitudinal study, including 200 patients with: glaucoma, suspected of having glaucoma, nonglaucomatous optic neuropathies, AMD, retinal degenerations, other diseases involving the visual pathways, besides healthy controls. Subjects will perform standard ophthalmological exams, and the following research tests: electroencephalogram, visual evoked potentials, and questionnaires. 3. Statistical analyses will be performed by the PI using the software Stata, MATLAB, and MPLUS. Risks are low, consisting of some discomfort, fatigue, dizziness or motion sickness.

NCT ID: NCT03305029 Enrolling by invitation - Clinical trials for Dry Age Related Macular Degeneration

The Safety and Tolerability of Sub-retinal Transplantation of SCNT-hES-RPE Cells in Patients With Advanced Dry AMD

Start date: May 2016
Phase: Phase 1
Study type: Interventional

To evaluate the safety and tolerability of human somatic cell nuclear transfer embryonic stem cell derived retinal pigmented epithelial(SCNT-hES-RPE) cellular therapy in patients with advanced dry AMD

NCT ID: NCT03205202 Enrolling by invitation - Cataract Clinical Trials

Cataract and AMD in a Trial of a Multivitamin and Cocoa Extract

COSMOS-Eye
Start date: June 1, 2015
Phase: Phase 4
Study type: Interventional

COSMOS-Eye is an ancillary study of the COcoa-Supplement and Multivitamins Outcomes Study (COSMOS; NCT02422745). COSMOS is a randomized clinical trial of cocoa extract supplement (containing a total of 500 mg/d flavanols, including 80 mg (-)-epicatechins), and a standard multivitamin supplement to reduce the risk of cardiovascular disease and cancer among men aged 60 years and older and women aged 65 years and older. This ancillary study is being conducted among participants in COSMOS and will examine whether the cocoa extract supplement or the multivitamin supplement reduces the risk of cataract and AMD, two leading causes of visual impairment in US men and women.

NCT ID: NCT03076697 Enrolling by invitation - Diabetes Mellitus Clinical Trials

Smartphone Screening for Eye Diseases

Start date: April 16, 2015
Phase:
Study type: Observational

To validate new screening instruments for eye disease, increase eye care access in underserved communities, and provide a scientifically implemented method to set up programs for eye disease screening.

NCT ID: NCT02747368 Enrolling by invitation - Clinical trials for Macular Degeneration

Evaluation of Visual Function and Driving Health Using Ocusweep in Patients Suffering From Wet Age-related Macular Degeneration

Start date: April 2016
Phase: N/A
Study type: Interventional

The aim is to study the use of Ocusweep system especially in driving health evaluation and compare the results produced by Ocusweep system to those of conventional devices. The main focus is in patients suffering from wet age-related macular degeneration. The study aims to find out how frequently these patients do not meet the European Union health criteria of safe driving and how Ocusweep finds these patients from a population of patients being treated in a busy medical retina clinic. The tests of Ocusweep system are compared against conventional visual field tests, contrast sensitivity tests, visual acuity tests and tests showing anatomical changes related to wet age-related macular degeneration (optical coherence tomography, fundus photography and fluorescein or indocyanine green angiography).

NCT ID: NCT01920867 Enrolling by invitation - Glaucoma Clinical Trials

Stem Cell Ophthalmology Treatment Study

SCOTS
Start date: August 2012
Phase: N/A
Study type: Interventional

This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease. http://mdstemcells.com/scots-ii/

NCT ID: NCT00951288 Enrolling by invitation - Clinical trials for Age-Related Macular Degeneration

Effect of Saffron Supplementation on Macular Cone-mediated Function in Age-related Macular Degeneration

safAMD
Start date: June 2009
Phase: Phase 1/Phase 2
Study type: Interventional

This is a pilot interventional study whose aim is to determine the effect of a dietary supplementation with a Crocus Sativus extract, Saffron, on macular cone-mediated function in patients with early age-related macular degeneration (AMD). Pre-clinical evidence ( Maccarone R, Di Marco S, Bisti S. Saffron supplement maintains morphology and function after exposure to damaging light in mammalian retina. Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1254-61.) indicates the potential effectiveness of Saffron as a retinal neuroprotectant in animal models of retinal degenerative disorders.The macular function will be tested by visual acuity and macular cone-mediated electroretinogram (focal electroretinogram, FERG) according to a standardized technique (see citations).