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Clinical Trial Summary

The purpose of this process is to clarify the characteristics of gut microbiota changes in patients with locally advanced rectal cancer undergoing preoperative neoadjuvant treatment, and to identify key bacterial species closely related to sensitivity to radiotherapy. This aims to elucidate the mechanism linking gut microbiome dysbiosis with radiotherapy sensitivity, thereby providing new combined treatment strategies to enhance the efficacy of radiotherapy.


Clinical Trial Description

The study is expected to enroll 100 patients with locally advanced rectal cancer, including 50 patients in the radiotherapy-sensitive group and 50 in the radiotherapy-resistant group. Each participant will provide stool and blood samples before treatment for subsequent metagenomic and metabolomic sequencing analysis. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06375434
Study type Observational [Patient Registry]
Source Xinjiang Medical University
Contact
Status Not yet recruiting
Phase
Start date May 15, 2024
Completion date August 31, 2024

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