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Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer — TRI-LARC  

Locally Advanced Rectal Cancer Clinical Trial

Official title:
Randomised Phase II Study of Pre-operative 3-D Conformal Radiotherapy (3-DCRT) Versus Intensity Modulated Radiotherapy (IMRT) for Locally Advanced Rectal Cancer

Clinical Trial Summary

The study aims to compare the incidence of acute grade 2 GI toxicity in the Control 3-D Conformal Radiotherapy compared to the Intensity Modulated Radiotherapy (IMRT) arm for locally advanced rectal cancer.

Clinical Trial Description

Pre-operative radiotherapy (RT) or chemo-radiotherapy (CRT) is internationally accepted as standard practice in the management of locally advanced rectal cancer. Multiple randomised trials have proved pre-operative CRT and RT, compared to surgery alone, reduce local recurrence, even prior to optimal surgery, and may improve survival for T3 circumferential resection margin (CRM) negative patients. This study aims to determine if 3-DCRT or IMRT result in lower incidence of grade 2 GI toxicities. Acute toxicities will be assessed weekly during radiotherapy, and at 2 and 4 week post treatment. Late toxicities will be assessed at 3, 6, 9, 12, 18, 24 months post treatment, and annually to 10 years. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02151019
Study type Interventional
Source Cancer Trials Ireland
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date October 17, 2014
Completion date July 21, 2020
View Details
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