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Dose-escalation Trial of Preoperative Radiotherapy and Concurrent Chemotherapy in Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer Clinical Trial

Official title:
Multicenter Dose-escalation Trial of Radiotherapy in Patients With Locally Advanced Rectal Cancer

Clinical Trial Summary

The aim of this study is to evaluate the increase of radiation dose administered in patients diagnosed with locally advanced rectal cancer in terms of ypRC with tolerable toxicity, using IMRT (concomitant boost technique).

Clinical Trial Description

The hypothesis that arises is an improvement in the proportion of pathological complete responses, resulting therapeutic gain, as a result of a higher dose of radiation delivered to the tumor volume without incurring a higher gastrointestinal toxicity to the patient or surgical complications later, thanks to the use of intensity modulated radiotherapy (concomitant boost technique) that allows us to significantly reduce the administered dose organs at risk. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02964468
Study type Interventional
Source Grupo de Investigación Clínica en Oncología Radioterapia
Contact Fernando López Campos, Investigator
Email flcampos@salud.madrid.org
Status Recruiting
Phase N/A
Start date September 2016
Completion date May 2020
View Details
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