Liver Diseases Clinical Trial
— MACRONUTROfficial title:
Study of the Role of Insulin Resistance in the Pathogenesis of the Metabolic Syndrome and of Non-alcoholic Steatohepatitis
Verified date | June 2018 |
Source | University of Lausanne |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to assess how the macronutrient composition of the diet effects
- lipid and glucose metabolism
- intrahepatic lipids
- insulin sensitivity
in healthy lean subjects and in subjects with a high metabolic risk (ie overweight and
offsprings of patients with type 2 diabetes mellitus).
Status | Completed |
Enrollment | 41 |
Est. completion date | January 2009 |
Est. primary completion date | April 2008 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Males and females - Age 18-40 - Informed consent obtained - Subgroup with overweight (body mass index [BMI] > 25) - Subgroup with family history of type 2 diabetes mellitus Exclusion Criteria: - Smokers - Alcohol intake > 30g/day - Drug abuse - Diabetes mellitus - Any concurrent medication - Having a pacemaker - History of orthopedic surgery - History of metal foreign bodies |
Country | Name | City | State |
---|---|---|---|
Switzerland | Centre Hospitalier Universitaire Vaudois | Lausanne |
Lead Sponsor | Collaborator |
---|---|
University of Lausanne |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | plasma triglycerides | 6 days | ||
Primary | intra-hepatic lipids | 6 days | ||
Primary | insulin mediated glucose disposal | 6 days | ||
Secondary | lipid oxidation | 6 days | ||
Secondary | plasma beta-hydroxybutyrate | 6 days | ||
Secondary | gene expression in skeletal muscle and adipose tissue | 6 days |
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