Relationship Between Central Sensitization and Kinesiophobia in Knee Osteoarthritis

Knee Osteoarthritis Clinical Trial

Official title:

The Relationship Between Central Sensitization and Kinesiophobia in Patients With Knee Osteoarthritis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06336278
• Other study ID #: 19/03/2024
• Status: Completed
• Start date: October 1, 2022
• Est. completion date: December 1, 2023

Study information

• Verified date: April 2024
• Source: Bulent Ecevit University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Objective: The knee joint is one of most common locations in OA. In recent years, it has been accepted that there are different pain phenotypes and patient subgroups in knee OA and that central sensitization (CS) mechanisms are at the forefront in some patients. It is also known that fear of movement, known as kinesiophobia, develops in patients with chronic pain. The aim of this study is to investigate CS and kinesiophobia in patients with knee OA, their relationships with each other, and their effects on pain intensity, functional status, pain catastrophizing and depression. Materials and Methods: Forty-two patients with knee OA and 42 healthy subjects participated in our study. Demographic data, body mass index, habits, comorbidities, medications of participants and disease duration and radiographic grade of knee OA patients were recorded. VAS was used to assess the severity of pain and WOMAC was used to assess pain and functional status in patients with OA. Algometer (pressure pain threshold measurement) and Central Sensitization Inventory were used to evaluate central sensitization in all participants. Pressure pain threshold (PPT) was measured at 3 different points: knee joint, cruris and forearm. The presence of kinesiophobia was assessed with the Tampa Scale af Kinesiophobia (TSK). Pain Catastrophizing Scale (PCS) and Beck Depression Inventory (BDI) were used to assess chronic pain related symptoms.

Description:

Forty-two patients with knee OA and 42 healthy subjects participated in our study. Demographic data, body mass index, habits, comorbidities, medications of participants and disease duration and radiographic grade of knee OA patients were recorded. VAS was used to assess the severity of pain and WOMAC was used to assess pain and functional status in patients with OA. Algometer (pressure pain threshold measurement) and Central Sensitization Inventory were used to evaluate central sensitization in all participants. Pressure pain threshold (PPT) was measured at 3 different points: knee joint, cruris and forearm. The presence of kinesiophobia was assessed with the Tampa Scale af Kinesiophobia (TSK). Pain Catastrophizing Scale (PCS) and Beck Depression Inventory (BDI) were used to assess chronic pain related symptoms.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 84
• Est. completion date: December 1, 2023
• Est. primary completion date: October 1, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 45 Years to 75 Years

Eligibility

Inclusion Criteria for knee osteoarthritis group:

• Being a healthy volunteer between the ages of 45-75
• Being diagnosed with knee osteoarthritis according to ACR diagnostic criteria
• Knee pain for at least 6 months
• Kellgren-Lawrence 1, 2 or 3 radiologic grade of knee OA
• Body mass index below 35

Exclusion Criteria for knee osteoarthritis group:

• Presence of chronic widespread painful diseases other than osteoarthritis (fibromyalgia syndrome etc.), rheumatologic disease, peripheral neuropathy
• Presence of uncontrolled systemic disease
• Cooperation limitation or cognitive impairment
• Active arthritis in the knee joint to be evaluated
• Presence of prosthesis in the knees
• Pain in the forearm
• Body mass index of 35 and above

Related Conditions & MeSH terms

• Central Sensitisation
• Kinesiophobia
• Knee Osteoarthritis
• Osteoarthritis
• Osteoarthritis, Knee

Intervention

Diagnostic Test:
• Pressure Algometer
Pressure algometer is used to detect pain pressure treshold.

Locations

Country	Name	City	State
Turkey	Zonguldak Bulent Ecevit Universitiy	Zonguldak

Sponsors (1)

Lead Sponsor	Collaborator
Selda Sarikaya

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pain Pressure Treshold	Algometer was used to detect pressure pain threshold. Higher scores mean better outcomes.	Day 1
Primary	Central Sensitization	Central Sensitization Inventory was used to evaluate central sensitization. Minimum value is 0 , maximum value is 100. Higher values means worse outcomes.	Day 1
Primary	Kinesiophobia	The presence of kinesiophobia was assessed with Tampa Scale af Kinesiophobia. Minimum value is 17 , maximum value is 68. Higher values means worse outcomes.	Day 1
Secondary	Pain Catastrophizing	Pain Catastrophizing Scale was used to assess chronic pain related symptoms. Minimum value is 0 , maximum value is 52. Higher values means worse outcomes.	Day 1
Secondary	Depression	Beck Depression Inventory was used to assess depression. Minimum value is 0 , maximum value is 63. Higher values means worse outcomes.	Day 1
Secondary	Visuel Analog Scala	Visuel Analog Scala was used to assess pain intensity. Patients' pain (0=no pain, 10=intolerable pain) on a 100 mm horizontal line. The marked value was recorded in millimeters.	Day 1
Secondary	Western Ontario and McMaster Universitesies Osteoarthritis Index	Pain and functional status of the patients included in our study assessment was performed using this index, consists of a total of three subscales and 24 questions, each question is scored between 0 and 4 (0=none, 4=very severe). Minimum value is 0, maximum value is 100. Higher scores indicate an increase in pain and stiffness and a decline in physical function.	Day 1