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Effect of Interleukin-6 Receptor Inhibition in Patients With Ischemic Stroke Undergoing Endovascular Treatment — IRIS  

Ischemic Stroke Clinical Trial

Official title:
Effect of Interleukin-6 Receptor Inhibition in Patients With Ischemic Stroke Undergoing Endovascular Treatment: a Double-blind, Randomized, Placebo-controlled Trial

Clinical Trial Summary

Tocilizumab may exert neuroprotective effects in patients with ischemic stroke undergoing endovascular treatment

Clinical Trial Description

Vascular recanalization techniques, including thrombolysis and thrombectomy, have become the mainstay of treatment for acute ischemic stroke. However, some patients still experience poor prognosis, with ineffective recanalization and reperfusion brain injury being the major contributors to unfavorable outcomes. Studies have indicated that tocilizumab, used in ST-segment elevation and non-ST-segment elevation myocardial infarction, exhibits anti-inflammatory and myocardial protective effects. Nevertheless, whether tocilizumab can provide neuroprotection in the early stages of acute large vessel recanalization remains uncertain. Given the above evidence, the aim of this study was to investigate whether combination therapy with tocilizumab in the early phase of recanalization of acute large vessel occlusion could further exert a beneficial effect and thus improve the poor prognosis of patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06238024
Study type Interventional
Source Suzhou Municipal Hospital of Anhui Province
Contact Zhengfei Ma, M.M.
Phone +8613866586362
Email Zhengfeima@126.com
Status Recruiting
Phase Phase 2/Phase 3
Start date February 2, 2024
Completion date September 30, 2025
View Details
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