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A Safety and Tolerability Study of Neural Stem Cells (NR1) in Subjects With Chronic Ischemic Subcortical Stroke (ISS)

Ischemic Stroke Clinical Trial

Official title:
A Phase 1/Phase 2a Safety and Tolerability Study of Intracerebral Transplantation of Neural Stem Cells (NR1) in Subjects With Chronic Ischemic Subcortical Stroke (ISS) and Early Evaluation of Potentially Useful Efficacy Parameters

Clinical Trial Summary

Evaluation of the safety and tolerability of escalating doses of NR1 administered intracerebrally at a single time-point post-injury to subjects with chronic ISS with or without cortical stroke.

Clinical Trial Description

Evaluation of the safety and tolerability of escalating doses of NR1 administered intracerebrally at a single time-point post-injury to subjects with chronic ISS with or without cortical stroke. The study will be a dose escalation using up to 4 cohorts each at a single dose level, of intracerebral administration of NR1 cells. Secondary objectives are to evaluate clinical and radiologic responses as well as utility of efficacy measurement tools. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04631406
Study type Interventional
Source Stanford University
Contact Clinical Research Coordinator
Phone 650-723-0508
Email stemcellstudy@stanford.edu
Status Recruiting
Phase Phase 1/Phase 2
Start date January 4, 2021
Completion date May 31, 2025
View Details
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