Stress Cardiac MRI in Ischemic Patients

Ischemic Cardiomyopathy Clinical Trial

Official title:

Assessment of Myocardial Viability by Cardiac Magnetic Resonance Feature Tracking at Rest and During Stress by Low Dose Dobutamine

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04588675
• Other study ID #: Stress cardiac MRI
• Status: Not yet recruiting
• Start date: November 2021
• Est. completion date: June 2022

Study information

• Verified date: October 2020
• Source: Assiut University
• Contact: Abdulrahman Hamdan
• Phone: 1005363950
• Email: abdulrahman.emam[@]med.au.edu.eg
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to assess the diagnostic accuracy of CMR feature-tracking (FT) at rest & during stress with low dose dobutamine (LDD) in the evaluation of viability in ischemic cardiomyopathy (ICM) patients and compare it with delayed gadolinium enhancement (DGE).

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: June 2022
• Est. primary completion date: December 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 75 Years

Eligibility

Inclusion Criteria:

• All patients recruited into the study have chronic LV systolic dysfunction due to coronary artery disease (CAD)

Exclusion Criteria:

• All patients with a contraindication to MR study:
• Patients with implanted non-MRI compatible electronic devices (e.g. Cardiac pacemakers, intracranial metallic clips, implanted hearing aids, etc.)
• Patients with foreign bodies in the eye.
• Claustrophobic patients.
• Patients diagnosed with recent acute coronary syndrome within 4 weeks.
• Patients who had contraindications for MRI or contrast agents, and those with poor image quality due to either inadequate breath holding or arrhythmias

Related Conditions & MeSH terms

• Cardiomyopathies
• Ischemia
• Ischemic Cardiomyopathy

Intervention

Diagnostic Test:
• MRI
the patients will underwent dobutamine stress cardiac MRI

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (2)

Bhutani M, Vatsa D, Rahatekar P, Verma D, Nath RK, Pandit N. Role of strain imaging for assessment of myocardial viability in symptomatic myocardial infarction with single vessel disease: An observational study. Echocardiography. 2020 Jan;37(1):55-61. doi: 10.1111/echo.14567. Epub 2019 Dec 23. — View Citation

Schuster A, Paul M, Bettencourt N, Morton G, Chiribiri A, Ishida M, Hussain S, Jogiya R, Kutty S, Bigalke B, Perera D, Nagel E. Cardiovascular magnetic resonance myocardial feature tracking for quantitative viability assessment in ischemic cardiomyopathy. Int J Cardiol. 2013 Jun 20;166(2):413-20. doi: 10.1016/j.ijcard.2011.10.137. Epub 2011 Nov 29. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	comparison of myocardial strain with late gadolinium enhancement	analysis of the myocardial strain by low dose dobutamine and test if it can assess myocardial viability	Baseline