Ischaemic Stroke Clinical Trial
Official title:
Penumbra and Recanalisation Acute Computed Tomography in Ischaemic Stroke Evaluation
Stroke affects over 125,000 people each year in the UK and leaves at least 50% disabled.
Treatment of stroke caused by a blockage in a blood vessel (ischaemic stroke), with
clotbusting drugs improves the chances of good recovery, but must be given within 4.5 hours
of onset. Currently only a small proportion of patients who arrive in hospital within 4.5
hours are treated. This is largely due to uncertainty about diagnosis and concerns about risk
of bleeding associated with clotbusting medication. Patients with mild or improving symptoms
in particular are often not treated because of uncertainty about relative risks and benefits.
However, around one third of these patients go on to be significantly disabled. Routine CT
scanning often does not show abnormalities in acute stroke (which take hours to become easily
visible), and cannot show the extent or severity of blood flow changes in ischemic stroke.
We wish to investigate the value of additional CT scanning that gives information on the
blood vessels (angiography, CTA) and blood flow to the brain (perfusion, CTP) by undertaking
a randomised trial. Extra scans are done in the same scanner and involve some extra
radiation, injections of a contrast dye, and some extra time to acquire process and
interpret. The extra scans may allow better treatment decisions for patients by increasing
diagnostic certainty and by better assessment of stroke severity. However, we do not know
whether the potential gains from better selection justify the resources and potential
treatment delays that are involved. We will investigate whether the proportion of patients
given clotbusting drugs differs between the two scanning protocols; and whether the outcomes
differ, using standard measures of disability. We will also investigate whether use of
different scanner manufacturers' software affect interpretation of scans.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03148457 -
Early Versus Late Initiation of Direct Oral Anticoagulants in Post-ischaemic Stroke Patients With Atrial fibrillatioN (ELAN): an International, Multicentre, Randomised-controlled, Two-arm, Assessor-blinded Trial
|
N/A | |
| Recruiting |
NCT05922540 -
a Cohort Study of Ischemic Cerebrovascular Disease
|
||
| Completed |
NCT02122718 -
XILO-FIST, the Effect of Allopurinol on the Brain Heart and Blood Pressure After Stroke
|
Phase 4 | |
| Completed |
NCT04260347 -
SITS-IVT in Patients >80 Years Study
|
||
| Completed |
NCT02205424 -
Cognition And Neocortical Volume After Stroke
|
||
| Completed |
NCT02117635 -
Pilot Investigation of Stem Cells in Stroke Phase II Efficacy
|
Phase 2 | |
| Recruiting |
NCT01665729 -
Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis
|
N/A | |
| Completed |
NCT02155907 -
Atrial Fibrillation Detected by ELR and Holter Recording, a Comparison in Patients With Ischemic Stroke or TIA
|
||
| Completed |
NCT02073773 -
Combinational Rehabilitative Therapy and Functional Brain Imaging for Patients Recovering From Motor Stroke
|
Phase 3 | |
| Active, not recruiting |
NCT01864031 -
The Role of Alcohol Consumption in the Aetiology of Different Cardiovascular Disease Phenotypes: a CALIBER Study
|
N/A | |
| Completed |
NCT02928926 -
Cerebral Haemodynamics in Stroke Thrombolysis Study (CHIST)
|