Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis

Ischaemic Stroke Clinical Trial

Official title:

Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01665729
• Other study ID #: 2011-2-48
• Status: Recruiting
• Phase: N/A
• First received: August 12, 2012
• Last updated: August 14, 2012
• Start date: June 2011
• Est. completion date: December 2015

Study information

• Verified date: August 2012
• Source: Third Affiliated Hospital, Sun Yat-Sen University
• Contact: Zhengqi Lu, prof.
• Phone: 86 13570102668
• Email: lzq1828[@]yahoo.com.cn
• Is FDA regulated: No
• Health authority: China: Ministry of Science and Technology
• Study type: Observational

Clinical Trial Summary

Negligence or contempt of the etiology and pathogenesis of minor ischaemic stroke in the early diagnosis and effective treatment leads to more than 40-50% of patient with recurrent episodes, and 10% patient died. Therefore, diagnosis and treatment of minor ischaemic stroke according to the etiology and pathogenesis is important.

The 2007 Korean modified TOAST type got some progress, but there exists two major disadvantages: imperfect diagnosis and pathogenesis of perforator artery infarction etiology; lack of typing according to the pathogenesis of large atherosclerotic infarction and taking measures of treatment according to the new types. Recently, domestic professor Gaoshan proposes new approach to diagnose and treat minor ischaemic stroke according to the etiology and pathogenesis of CISS typing, but the pathogenesis of hypoperfusion infarction with severe stenosis of large artery is unclear. Is it low perfusion? Or artery-artery embolization? Or both? How to distinguish the pathogenesis of branch artery disease: by atherosclerosis? Or hyalinosis? Or both? How to check the validity of clinical types? This study take different interventions according to different types and observation of the long term clinical results of intervention( mortality, recurrence rate, disability rate and rate of cerebral hemorrhage and subarachnoid hemorrhage), in order to clarify the new types can indeed solve the current problem of minor ischaemic stroke with high mortality, recurrence rate, disability rate and rate of cerebral hemorrhage and subarachnoid hemorrhage.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 1000
• Est. completion date: December 2015
• Est. primary completion date: August 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 20 Years to 79 Years

Eligibility

Inclusion Criteria:

one of two conditions:

1. conscious patients with any of NIHSS score = 1,or

2. NIHSS = 3

Exclusion Criteria:

• patients Over 80 years of age

• patients With serious heart, lung, liver, kidney dysfunction or

• severe systemic complications,

• a known tumor,

• pregnancy,

• having a history of cerebral hemorrhage

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

• Ischaemic Stroke
• Ischemia
• Stroke

Locations

Country	Name	City	State
China	Department of Neurology,The Third Af?liated Hospital of Sun yat-sen University	Guangzhou	Guangdong

Sponsors (1)

Lead Sponsor	Collaborator
Li Haiyan

Country where clinical trial is conducted

China,