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Clinical Trial Summary

Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle. However in restoring the supply of blood local damage known as "ischaemia-reperfusion injury" may occur. The aim of this study is to assess how clot forming and clot dissolving pathways are affected during this process, and examine the role of a natural inflammatory hormone, bradykinin. This will help us to understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new treatments for heart attacks.


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Basic Science


Related Conditions & MeSH terms


NCT number NCT00789451
Study type Interventional
Source University of Edinburgh
Contact
Status Completed
Phase N/A
Start date August 2008
Completion date October 2010

See also
  Status Clinical Trial Phase
Completed NCT00789243 - The Effect of Ischaemic-Reperfusion and Ischaemic Preconditioning on the Endogenous Fibrinolysis in Man N/A
Recruiting NCT03766529 - Loop Isolation-based Uploading Pre-conditioning
Completed NCT00351260 - BBC ONE - British Bifurcation Coronary Study Phase 3
Completed NCT00965120 - The Effect of Ischaemic-Reperfusion in Man - A Bradykinin Dependent Pathway N/A
Completed NCT00965393 - The Effect of Ischaemic-Reperfusion and Remote Ischaemic Preconditioning in Man - A Bradykinin Dependent Pathway N/A