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Efficacy and Safety Profile of Cisatracurium Besylate for IAH

Intra-abdominal Hypertension Clinical Trial

Official title:
Efficacy and Safety Profile of Cisatracurium Besylate for Intra-abdominal Hypertensiona: Single Center, Randomized, Controlled Trial

Clinical Trial Summary

This study is a randomized, double-blinded, controlled design. In this study, Cisatracurium Besylate was selected for treatment in Intra-abdominal hypertension or abdominal compartment syndrome,accompanied with evaluating the effects on the duration of organ failure,length of hospital stay and mortality.To clarify the effect of Cisatracurium Besylate on IAH/ACS is of great significance to the clinical applications.

Clinical Trial Description

1. Title: Title: Efficacy and Safety Profile of Cisatracurium Besylate on Intra-abdominal hypertension: A Randomized Clinical Trial 2. Research center: single center 3. Design of the research: A randomized, double-blind and parallel controlled study 4. Object of the research: The patients over 18 years that Intra-abdominal pressure over 12mmHg. 5. Sample size of the research: A total of 80patients,40 cases in each group 6. Interventions: Participants in the test group received Cisatracurium Besylate 0.12mg/kg/hr continuous infusion during intubation.while participants in the control group was the same as the test group except for received the same volume of saline instead of Cisatracurium Besylate.TOF-Watch was used to monitor the function of nerve and muscle in two groups and the dose was adjusted according to the TOF value. 7. The aim of the research:To investigate the effect of Cisatracurium Besylate on IIntra-abdominal hypertension or abdominal compartment syndrome. 8. Outcome #Primary outcomes: mortality. Secondary outcomes: Duration of organ failure; Time for enteral nutrition to reach the standard (30kcal/kg); Mechanical ventilation time; Length of hospital stay 9. The estimated duration of the study#1-2years ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05172531
Study type Interventional
Source Tianjin Nankai Hospital
Contact Ya Wu
Phone 15364689975
Email yawu223202@163.com
Status Not yet recruiting
Phase N/A
Start date August 29, 2022
Completion date April 1, 2023
View Details
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