Schizophrenia Clinical Trial
Official title:
Exploration of Neural Bases in Social Cognition
An impairment in social cognition in schizophrenia could account for the severe professional
and social difficulties among patients. Social cognition is the way the social world is
understood, perceived and interpreted. It includes all the process than enable oneself to
interact with another person, namely emotion perception and processing, theory of mind
(ToM), social perception, social knowledge and attributional style. Since these process are
interconnected, social cognition should be investigated through ecological tasks which
activate all of them together. Developing a social cognition ecological task, then testing
the reproducibility of the functional magnetic resonance imagery (fMRI) BOLD signal is the
main objective of this study. The secondary objective is to seek a functional deficit among
the neural network of social cognition in patients with schizophrenia compared with healthy
subjects.
Forty healthy subjects, aged from 18 to 60 years old, who have given a written consent, will
be included. The social cognition paradigm will be developed and the fMRI activations will
be compared to those of a visual cartoon based task, known to turn on the neural network of
ToM. BOLD signal variations at a high statistical correction ratio (p<0.05) will be explored
and compared to the signal of a second fMRI, made on the same 20 healthy subjects one month
later, to test reproducibility (% of identical activated voxels during the 2 fMRI, p<0.05).
Twenty matched patients with schizophrenia (DSM-IV-R), aged from 18 to 60 will be included
to test the secondary objective. We make the hypothesis of a fMRI functional alteration in
the cerebral network involved in social cognition, especially in the medial prefrontal
cortex, among patients compared with healthy subjects.
Social cognition neural basis. Impairment of the "social brain" in schizophrenia ;
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research
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