Acute Microbial Switch

Status Not yet recruiting

Clinical Trial Summary

In this project the investigators will test if it is possible to measure changes in intestinal gas production after supplementation of a complex fiber mixture over a 36 hour period in both lean normoglycemic individuals and individuals with insulin resistance and/or prediabetes with overweight when compared with a placebo Changes in intestinal gas production will also be related to energy expenditure, substrate metabolism, microbial composition and related metabolites in feces, blood and urine.

Clinical Trial Description

In this project the investigators aim to test whether it is possible to precisely measure the changes in fermentation gas patterns after supplementation of a complex fibre mixture over a 36-hour period in both lean normoglycemic and individuals with insulin resistance and/or prediabetes with overweight when compared with a placebo. Additionally, the investigators will investigate whether changes in fermentation patterns will be directly related to changes in carbohydrate and fat oxidation and to microbial composition or related metabolites and hormones in blood, faeces, and urine. ;

Study Design

Related Conditions & MeSH terms

Glucose Metabolism Disorders
Glucose Metabolism Disorders (Including Diabetes Mellitus)
Hyperinsulinism
Hypersensitivity
Insulin Resistance
Insulin Sensitivity
Metabolic Diseases

Clinical Trial Details

NCT number	NCT05764200
Study type	Interventional
Source	Maastricht University Medical Center
Contact	Gillian Larik, Msc
Phone	0433881641
Email	g.larik@maastrichtuniversity.nl
Status	Not yet recruiting
Phase	N/A
Start date	July 1, 2023
Completion date	October 31, 2025

View Details

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