Mitochondrial Remodeling After Exercise

Insulin Resistance Clinical Trial

Official title:

Mitochondrial Remodeling After Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04103424
• Other study ID #: IRB-2019-0124
• Status: Completed
• Phase: N/A
• Start date: August 23, 2019
• Est. completion date: December 3, 2022

Study information

• Verified date: February 2024
• Source: Oregon State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Regulation of mitochondrial health in overweight and obese individuals may be impaired. The purpose of this study is to identify impairments in regulation of mitochondrial health within skeletal muscle and to determine if short-term exercise training (2-weeks) can reverse such impairments. The investigator's hypothesis is that pathways that serve to degrade poorly functioning mitochondria in overweight and obese individuals are down-regulated, but that short-term exercise training can restore these pathways to improve skeletal muscle mitochondrial function.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 31
• Est. completion date: December 3, 2022
• Est. primary completion date: November 25, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Age 18-45 years

• Body mass index (BMI) 18-45 kg/m2

• Sedentary (<1 hour of planned exercise per week)

Exclusion Criteria:

• Regular exercise (>1 hour of planned exercise per week)

• Smoking, tobacco or nicotine use within the last 1-year

• Fasting glucose >126mg/dL

• Hypertension (systolic pressure >140 mmHg or diastolic pressure >90 mmHg)

• Chronic metabolic or cardiovascular health conditions

• Pregnant, nursing, irregular menses or post-menopausal

• Lidocaine allergy

• Certain medications

• Physical limitations that prevent safe or successful exercise completion

• Diminished capacity for consent

Related Conditions & MeSH terms

• Insulin Resistance
• Metabolic Disease
• Metabolic Diseases
• Mitochondrial Metabolism
• Overweight
• Overweight and Obesity
• Sedentary Lifestyle

Intervention

Behavioral:
• Short-term Exercise Training
Participants will perform 2-weeks of supervised exercise training on a stationary bike.

Locations

Country	Name	City	State
United States	Oregon State University	Corvallis	Oregon

Sponsors (1)

Lead Sponsor	Collaborator
Oregon State University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in skeletal muscle mitochondrial protein degradation peptide products	Skeletal muscle mitochondrial protein degradation peptide products after 2-weeks of exercise training compared with before training.	After 2-weeks of exercise training compared with before training.