Inflammation Clinical Trial
The research aims to determine the impact of 30-day supplementation of melatonin on the antioxidative defense mechanisms and the release of markers of oxidative stress and inflammation in rowers and footballers undergoing training of submaximal intensity.
Athlete's body, by its high oxygen demand and increased aerobic metabolism, is exposed to the
formation and oxidizing action of reactive oxygen species (ROS). Imbalance between the
mechanisms of ROS generation and antioxidative defense of the body can lead to oxidative
stress expressed by elevated concentrations of lipid peroxidation products, such as
malondialdehyde, isoprostanes (8-iso-PGF2α), oxidized low-density lipoprotein molecules
(ox-LDL). The body's defense against ROS includes two systems: nonenzymatic and enzymatic.
Small-molecule antioxidants include reduced glutathione (GSH). Due to the presence of -SH
groups, glutathione has strong reductive properties. The compound is a substrate for
glutathione peroxidase (GSH-Px) which decomposes hydrogen peroxide and organic peroxides.
Among antioxidant enzymes are also: superoxide dismutase (Cu-Zn-SOD, scavenges superoxide
anion radical), catalase (CAT, reduces hydrogen peroxide), and glutathione reductase (GR,
reduces oxidized glutathione). Another well-known small-molecule antioxidant is melatonin,
hormone of the pineal gland. It has been demonstrated that this compound can reduce hydrogen
peroxide, scavenge hydroxyl radical and deactivate nitric oxide radical.
Another manifestation of disruption of homeostasis in the body of a professional athlete are
enhanced inflammatory processes. This can be explained by the fact that during physical
effort of varied intensity, increased activity of myeloperoxidase and higher levels of mRNA
for tumor necrosis factor, interleukin-1 and -6 are observed. Interleukin-6, also known as
myokine, is a particularly important marker of intense physical effort released from damaged
muscles. Myokine is also the main upregulator of the synthesis of C-reactive protein (CRP) in
the liver, hence measuring the concentration of the protein can indicate the intensity of
inflammatory processes in an athlete's body. It has been demonstrated that melatonin, in
addition to its hormonal and antioxidant properties, can modulate inflammatory processes by
reducing the synthesis of proinflammatory cytokines.
Taking into account the multidirectional function of melatonin, it seems interesting to
establish the impact of 30-day supplementation of this hormone on the antioxidative defense
mechanisms and the release of markers of oxidative stress and inflammation in rowers and
footballers undergoing training of submaximal intensity.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03995979 -
Inflammation and Protein Restriction
|
N/A | |
| Completed |
NCT03255187 -
Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution
|
N/A | |
| Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
| Completed |
NCT03577223 -
Egg Effects on the Immunomodulatory Properties of HDL
|
N/A | |
| Completed |
NCT04383561 -
Relationship Between LRG and Periodontal Disease
|
N/A | |
| Active, not recruiting |
NCT03622632 -
Pilot Study to Measure Uric Acid in Traumatized Patients: Determinants and Prognostic Association
|
||
| Completed |
NCT06216015 -
Exercise Training and Kidney Transplantation
|
N/A | |
| Completed |
NCT04856748 -
Nomogram to Diagnose Prostatic Inflammation (PIN) in Men With Lower Urinary Tract Symptoms
|
||
| Completed |
NCT05529693 -
Efficacy of a Probiotic Strain on Level of Markers of Inflammation in an Elderly Population
|
N/A | |
| Recruiting |
NCT05415397 -
Treating Immuno-metabolic Depression With Anti-inflammatory Drugs
|
Phase 3 | |
| Recruiting |
NCT05670301 -
Flemish Joint Effort for Biomarker pRofiling in Inflammatory Systemic Diseases
|
N/A | |
| Recruiting |
NCT05775731 -
Markers of Inflammation and of the Pro-thrombotic State in Hospital Shift and Day Workers
|
||
| Recruiting |
NCT04543877 -
WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study
|
Early Phase 1 | |
| Completed |
NCT03859934 -
Metabolic Effects of Melatonin Treatment
|
Phase 1 | |
| Completed |
NCT03429920 -
Effect of Fermented Soy Based Product on Cardiometabolic Risk Factors
|
N/A | |
| Completed |
NCT06065241 -
Quantifiably Determine if the Botanical Formulation, LLP-01, Has a Significant Clinical Effect on Proteomic Inflammatory Biomarkers and Epigenetic Changes in Healthy, Older Individuals.
|
N/A | |
| Completed |
NCT05864352 -
The Role of Dietary Titanium Dioxide on the Human Gut Microbiome and Health
|
||
| Completed |
NCT03318731 -
Efficacy and Safety of Fenugreek Extract on Markers of Muscle Damage and Inflammation in Untrained Males
|
N/A | |
| Not yet recruiting |
NCT06134076 -
Comparing Effects of Fermented and Unfermented Pulses and Gut Microbiota
|
N/A | |
| Not yet recruiting |
NCT06422494 -
The Role of the Adrenergic System in Hypoglycaemia Induced Inflammatory Response in People With Type 1 Diabetes and People Without Type 1 Diabetes-RAID-II
|
N/A |