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Comparing the Effect of Sitagliptin/Metformin and Metformin in PCOS Patients

Infertility Clinical Trial

Official title:
Comparing the Therapeutic Effect of Sitagliptin/Metformin and Metformin on Biochemical Factors and Expression of GDF-9 and BMP-15 Genes in Patients With Classic PCOS Undergoing Intra-cytoplasmic Sperm Injection (ICSI)

Clinical Trial Summary

Investigators will evaluate and compare the efficacy of Sitagliptin/Metformin to metformin and sitagliptin on gdf9 and bmp15 gene expression on PCOS patients undergoing intracytoplasmic sperm injection(ICSI).

Clinical Trial Description

This study was conducted in Infertility clinic of Mahdiyeh Educational Hospital, Tehran. Patients in the four groups receive the drug 2 months before the start of the ovulation cycle, and treatment will continue until the day of the oocyte aspiration. The drug provide by midwife to patients and both patient and physician blind to the treatment regimen. The participants randomly divide into four groups.The ovulation induction stimulate with GnRh antagonist. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04268563
Study type Interventional
Source Shahid Beheshti University of Medical Sciences
Contact Delbar Daneshjou, PHD student
Phone 989120823342
Email db.daneshjou@gmail.com
Status Recruiting
Phase Phase 1/Phase 2
Start date January 10, 2020
Completion date July 30, 2021
View Details
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