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Infections clinical trials

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NCT ID: NCT05474118 Completed - Infectious Disease Clinical Trials

Real-life Use of Cefazolin for the Treatment of Meticillin-susceptible Staphylococcal Infective Endocarditis: Comparison to a Treatment Cohort With Penicillin M

CEFASTA
Start date: February 5, 2020
Phase:
Study type: Observational

Retrospective, regional, multicenter study (including the Annecy-Genevois Hospital Center, the Chambéry Métropole Savoie Hospital Center, and the Grenoble University Hospital Center), comparing a cohort of patients treated with Cefazolin with a cohort of patients treated with Penicillin M

NCT ID: NCT05473325 Not yet recruiting - Obesity Clinical Trials

Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)

BRANCH-P
Start date: January 1, 2023
Phase:
Study type: Observational

This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop Nuclear Magnetic Resonance (NMR) spectroscopy in human clinical pathology. This is an instrument assessment study for point of care viability which will also result in enhanced patient care (pending their consent) in blood screenings and metabolic health data.

NCT ID: NCT05472779 Recruiting - Clinical trials for Recurrent Urinary Tract Infection

Periurethral vs Intravaginal Estrogen for Prevention of Recurrent Urinary Tract Infections

TAPER
Start date: January 3, 2023
Phase: Phase 2
Study type: Interventional

Due to rising antibiotic resistance, there has been a focus on non-antibiotic prophylactic measures for postmenopausal patients with recurrent urinary tract infections (rUTI), one of which is the safe and efficacious option of vaginal estrogen therapy. Standard application of vaginal estrogen cream entails intravaginal application of the cream twice a week, but some providers counsel patients with rUTI to apply a small, pea-sized amount to the periurethral area. This ideally reduces the amount of vaginal estrogen used while attaining a similar effect. However, to date, there is no data to prove that the periurethral technique of application is similar or non-inferior to intravaginal application in preventing UTI.

NCT ID: NCT05472090 Completed - COVID-19 Clinical Trials

A Phase 2 Study to Evaluate the Efficacy and Safety of TNX-102 SL in Patients With Multi-Site Pain Associated With Post-Acute Sequelae of SARS-CoV-2 Infection

PREVAIL
Start date: August 18, 2022
Phase: Phase 2
Study type: Interventional

This is a Phase 2, randomized, parallel-group, double-blind, placebo-controlled, 14-week study designed to evaluate the efficacy and safety of TNX-102 SL 5.6 mg (2 x 2.8 mg tablets) taken once daily at bedtime for the management of multi-site pain associated with Long COVID.

NCT ID: NCT05471973 Recruiting - Infections Clinical Trials

CIED Infection Quality Initiative Demonstration Project

RECTIFY
Start date: May 10, 2023
Phase: N/A
Study type: Interventional

The aim of this Quality Initiative (QI) demonstration project is to develop a model to increase guideline-driven care for patients with cardiovascular implantable electronic devices (CIED) infection. Multidisciplinary teams will be established to carry out the multifaceted intervention. This program seeks to improve early identification and diagnosis, appropriate treatment, and faster time to treatment of CIED infection.

NCT ID: NCT05471908 Recruiting - Pneumonia Clinical Trials

Follow-up Automatically vs. As-Needed Comparison (FAAN-C) Trial

FAAN-C
Start date: August 22, 2022
Phase: N/A
Study type: Interventional

Compare the effectiveness of automatic vs as-needed (PRN) post-hospitalization follow-up for children who are hospitalized for common infections.

NCT ID: NCT05471726 Recruiting - Infections Clinical Trials

Improving Post-discharge Antimicrobial Use

Start date: May 22, 2023
Phase: N/A
Study type: Interventional

One in five hospitalized patients is prescribed an antimicrobial at the time of discharge, and a large proportion of these post-discharge antimicrobials are unnecessary. The investigators will evaluate a novel method for reviewing post-discharge antimicrobial prescriptions in real-time with the goal of improving antimicrobial selection and duration.

NCT ID: NCT05471661 Recruiting - Clinical trials for Bone Marrow Transplant Infection

T Lymphocytes for the Treatment of AdV, CMV, EBV, BKV and Aspergillus Fumigatus Infections After Allogeneic Stem Cell Transplantation

Penta-STs-001
Start date: January 24, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of the study is to determine the feasibility, safety and efficacy of administering rapidly-generated donor-derived pentavalent-specific T cells (Penta-STs) to mediate antiviral and antifungal activity in hematopoietic stem cell transplant (HSCT) recipients with AdV, EBV, CMV, BKV or Aspergillus fumigatus (AF) infection/ reactivation or with active disease.

NCT ID: NCT05469685 Completed - Clinical trials for Helicobacter Pylori Infection

Efficacy and Safety of Dual Therapy for Helicobacter Pylori Eradication

Start date: August 1, 2022
Phase: Phase 4
Study type: Interventional

The purpose of this study was to evaluate the Efficacy and Safety of Vonoprazan- amoxicillin dual therapy for Helicobacter Pylori eradication

NCT ID: NCT05468723 Completed - Infectious Diseases Clinical Trials

Evaluating Patient Comfort and Environmental Conditions in the Carecube Negative Pressure Isolation Chamber.1

Start date: May 24, 2022
Phase:
Study type: Observational

This is a human non-significant risk (NSR) clinical study designed to objectively and participatively verify that the Carecube Negative Pressure Isolation Chamber is a safe and non-hostile environment for the patients that will be contained within the chamber during normal operations.