Clinical Trials Logo

Immune Deficiency clinical trials

View clinical trials related to Immune Deficiency.

Filter by:
  • Completed  
  • Page 1 ·  Next »

NCT ID: NCT05792891 Completed - Frailty Clinical Trials

Approaches and Metrics in Fraily Patients During COVID-19 Era

COMETA
Start date: December 22, 2020
Phase:
Study type: Observational

The COVID-19 pandemic started in December 2019 in Wuhan, the Chinese province of Hubei. Compared to the period of the first epidemic wave (March to May 2020), in the period of the second epidemic wave (October 2020 to July 2021), deceased people have a more significant clinical complexit, as demonstrated by the higher number of comorbidities.The need to allocate significant amounts of healthcare resources to the COVID-19 emergency, deferral of routine healthcare visits, and invitation to avoid medical controls, if not strictly necessary, may have led to interruptions of disease management undersupply of chronic treatments. Consequently, the health status of patients with chronic pathologic conditions have worsened during and beyond the crisis. Patients with cancer, autoimmune disease, and immune deficiencies represented populations with varying immunocompetence, which made translate into higher susceptibility to SARS-CoV-2 and, for this reason, we defined them as frail populations.The main goal of the study was to propel the field of COVID-19 impact on particularly vulnerable categories of patients. The findings of this study could aid in determining the conditions under which healthcare organizations must operate in the event of a pandemic in order to protect patient's rights to care.

NCT ID: NCT05256784 Completed - Immune Deficiency Clinical Trials

Mountain Food and Natural Probiotic in Nutrition

Start date: September 15, 2021
Phase:
Study type: Observational

Background/Objectives: The research discusses the importance of mountain foods/products and services in the context of healthier nutrition and behavior with the application to agribusiness. The purpose of the research is to highlight the necessity of human behavior in consuming mountain products as natural probiotics. Subjects/methods: As evidence, the research analyses mountain food and the associated entrepreneurship for Austria and other Central and Eastern European countries (foods/products and services), especially from the mountain area. The authors realized experimental research regarding representative mountain food from Central and Eastern European areas and used the Eurostat database. Data has been taken from Eurostat and processed in Excel and SPSS, using similar models of analysis from published research. Experimental analysis has been realized by the authors and collected from different recognized sources.

NCT ID: NCT04979065 Completed - Covid19 Clinical Trials

Nutrition, Immunity, and Covid-19 in Obese People

NICO
Start date: July 24, 2021
Phase: Phase 2
Study type: Interventional

The increased risk of transmission of COVID-19 infection causes the incidence of death in health workers to escalate. It requires further research on risk factors and intervention in health worker professionals, especially on immunity factors and nutritional status. Quality of diet and nutrition is very important to support the immune system when infected. Several probiotic strains have been shown to decrease the duration and incidence of diarrhea and respiratory infections, suggesting the Gut-Lung Axis pathway. Some probiotics also improve the balance of diversity in the composition of the gut microbiota and affect body weight in obese people. Probiotics have also been shown to improve vitamin D absorption. A combination of vitamin D and probiotics may be an alternative to reduce gut dysbiosis that will directly or indirectly reduce the risk and severity of viral infections including SARS-CoV-2.

NCT ID: NCT04698759 Completed - Stunting Clinical Trials

Immune and Scfa Profile of Stunting Children

Start date: January 9, 2020
Phase:
Study type: Observational

1. Type and Research Design A cross-sectional study design with a quantitative approach will be conducted. Cross-sectional research design is one-time research to find a relationship between the independent variable (risk factor) and the dependent variable (effect). 2. Time and Location of Research The research will be conducted for approximately six months in 2020 at Banten Regency (namely Tegal Ongok and Pasirkarang) and Sumedang Regency. 3. Population and Research Sample The population is children between three and five years old in the village of stunting locus. The sampling method to be used in this research was quota sampling, namely 50 stunting and 50 healthy children from each Regency.

NCT ID: NCT04643639 Completed - Sepsis Clinical Trials

Assessing the Effects of CytoSorb Hemoperfusion on the Development on Immunoparalysis

EndoSorb
Start date: September 16, 2020
Phase: Phase 3
Study type: Interventional

In this randomized, open-label study, the investigators will assess whether CytoSorb hemoperfusion will prevent or attenuate the development of immunoparalysis in healthy volunteers undergoing repeated experimental endotoxemia.

NCT ID: NCT03968211 Completed - Immune Deficiency Clinical Trials

Undetectable IgE as a Sentinel Biomarker for Humoral Immunodeficiency

Start date: July 1, 2019
Phase: Phase 1
Study type: Interventional

This study is trying to find out if an undetectable serum immunoglobulin E (IgE) is a biomarker, or early sign of, the development of immune deficiency.

NCT ID: NCT03899480 Completed - HIV Infections Clinical Trials

Adoptive Transfer of Haploidentical NK Cells and N-803

Start date: May 1, 2019
Phase: Phase 1
Study type: Interventional

This is a pilot therapeutic study of related donor HLA-haploidentical NK-cell based therapy to determine if the treatment is safe and well-tolerated and if there is any measureable impact on virus reservoirs.

NCT ID: NCT03881566 Completed - Sepsis Clinical Trials

Presepsin as Detective Marker of Sepsis in Immunodeficiency ICU Patients

PREICU
Start date: March 1, 2019
Phase:
Study type: Observational

This is an observational study to evaluate the diagnostic and prognostic value of presepsin in the critically-ill immunocompromise patients.

NCT ID: NCT03609840 Completed - Sickle Cell Disease Clinical Trials

Study of Thiotepa and TEPA Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant Patients

Start date: May 24, 2017
Phase:
Study type: Observational

Thiotepa is a chemotherapy drug used extensively in bone marrow transplantation. Thiotepa is a prodrug that undergoes metabolic conversion in the liver by CYP2B6 and CYP3A4 to its primary active metabolite, triethylene phosphoramide (TEPA). The goal of this study is to determine what causes some children to have different drug concentrations of thiotepa and TEPA in their bodies and if drug levels are related to whether or not a child experiences severe side-effects during their bone marrow transplant. The hypothesis is that certain clinical and genetic factors cause changes in thiotepa and TEPA drug levels in pediatric bone marrow transplant patients and that high levels may cause severe side-effects.

NCT ID: NCT03052491 Completed - Quality of Life Clinical Trials

Effects of a 10 Component Dietary Supplement on Health and the Quality of Life

Start date: March 12, 2016
Phase: N/A
Study type: Interventional

This open-label field trial evaluates the effects of treatment with a multi-pathway dietary supplement (Stem Cell 100+) that has been commercially available for several years. The objective of the intervention trial is to determine if normal subjects over 35 years of age experience any observable health benefits from the dietary supplement as to their blood pressure, pulse rate, blood cholesterol, lung capacity, stress levels, or self reported changes in markers of overall health and life expectancy.