Hypertension Clinical Trial
Official title:
A Multi-center Randomised Controlled Trial to Explore the Ideal Individualized Anti-hypertension Strategies in Patients With Severe Stroke at Acute Stage
The purpose of this academic lead study is to explore ideal blood pressure targets and optimum individualized anti-hypertension strategies in acute severe stroke.
Of high mortality and morbidity, severe stroke is associated with devastating damages in
neurologic, respiratory, circulatory and many other systems. The outcomes of patients with
severe stroke depend largely on medical strategies on acute stage, especially on blood
pressure (BP) management. Unfortunately, so far no ideal BP range has been scientifically
determined for patients with acute severe stroke.
The CHASE study aims to provide reliable data on the effects of individualized
anti-hypertension strategy in patients with acute severe stroke (target recruitment 250)
compared to standard guideline-based management of BP (target recruitment 250). Patients
presenting with acute (<72h) severe stroke (GCS ≦ 12 or NIHSS ≧ 11) and elevated BP (systolic
blood pressure ≧150 mmHg or diastolic blood pressure ≧ 100 mmHg) will be randomly assigned to
individualized anti-hypertension treatment or guideline-based treatment for 7 days.
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