Hypertension Clinical Trial
Background:
Cardiovascular disease (CVD), osteoporosis and dementia are chronic diseases of ageing that
impact adversely on the lives of those affected and have major health, social and economic
consequences. A number of factors are considered to be implicated in these diseases, ranging
from the more established factors to those that are less well recognised. Lifestyle factors
such as diet, body weight, smoking, physical activity and years of education are
acknowledged as risk factors for the development of these chronic diseases of aging.
Emerging research suggests that elevated homocysteine and/or sub-optimal status of the
metabolically related B-vitamins (folate, vitamin B12, B6 and riboflavin) may be associated
with a higher risk of age-related disease. The interplay between relevant genetic and
nutrient factors (gene-nutrient interactions) is considered to be highly relevant in the
development (and prevention) of chronic diseases of ageing, however this relatively new area
of research is as yet poorly understood. The collection of clinical, lifestyle, nutritional
and genetic data on large numbers of patients would permit the investigation of those
nutrients which interact with specific genes to increase the likelihood of a person
developing chronic diseases of ageing.
Aim:
The aim of the TUDA study is to collect detailed clinical, lifestyle, dietary, genetic and
biochemical data to investigate gene-nutrient interactions (particularly from the
perspective of the B-vitamins and vitamin D/calcium) in the development of CVD, osteoporosis
and dementia by studying older adults exhibiting the early stages of these common diseases,
namely hypertension, low bone mineral density, and early memory loss, respectively.
Secondary aim (follow up TUDA investigation):
The aim of this longitudinal investigation is to re-assess clinical, nutritional, genetic
and biochemical factors in relation to the progression of disease outcomes in TUDA study
participants, in subsequent years after initial investigation.
Study design:
A total of 6000 non-institutionalised older Irish people aged over 60 years with early
predictors of either dementia, stroke and osteoporosis (namely early memory loss, high blood
pressure and low bone mineral density, respectively) recruited from three centres (St
James's Hospital Dublin, Ulster University Coleraine and The Clinical Translational Research
and Innovation Centre (C-TRIC), Londonderry) across Ireland. Non-fasting blood samples were
collected from all subjects and routine blood biochemistry profiles and biomarkers of
relevance to B vitamin and vitamin D status were measured. Supplement use was recorded and a
targeted food frequency questionnaire was used to record dietary intakes of specific
vitamins of interest (folate, B12, B6, riboflavin and D) from major food sources,
particularly fortified foods. Physiological function tests including blood pressure, bone
health (DXA scans) and cognitive function tests and anthropometric measures were also taken.
n/a
Observational Model: Cohort, Time Perspective: Cross-Sectional
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT04591808 -
Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia
|
Phase 3 | |
| Recruiting |
NCT04515303 -
Digital Intervention Participation in DASH
|
||
| Completed |
NCT05433233 -
Effects of Lifestyle Walking on Blood Pressure in Older Adults With Hypertension
|
N/A | |
| Completed |
NCT05491642 -
A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses
|
Phase 1 | |
| Completed |
NCT03093532 -
A Hypertension Emergency Department Intervention Aimed at Decreasing Disparities
|
N/A | |
| Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
| Completed |
NCT05529147 -
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
|
||
| Recruiting |
NCT06363097 -
Urinary Uromodulin, Dietary Sodium Intake and Ambulatory Blood Pressure in Patients With Chronic Kidney Disease
|
||
| Recruiting |
NCT05976230 -
Special Drug Use Surveillance of Entresto Tablets (Hypertension)
|
||
| Completed |
NCT06008015 -
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1015" and Co-administration of "BR1015-1" and "BR1015-2" Under Fed Conditions in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT05387174 -
Nursing Intervention in Two Risk Factors of the Metabolic Syndrome and Quality of Life in the Climacteric Period
|
N/A | |
| Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
| Recruiting |
NCT05121337 -
Groceries for Black Residents of Boston to Stop Hypertension Among Adults Without Treated Hypertension
|
N/A | |
| Withdrawn |
NCT04922424 -
Mechanisms and Interventions to Address Cardiovascular Risk of Gender-affirming Hormone Therapy in Trans Men
|
Phase 1 | |
| Active, not recruiting |
NCT05062161 -
Sleep Duration and Blood Pressure During Sleep
|
N/A | |
| Completed |
NCT05087290 -
LOnger-term Effects of COVID-19 INfection on Blood Vessels And Blood pRessure (LOCHINVAR)
|
||
| Not yet recruiting |
NCT05038774 -
Educational Intervention for Hypertension Management
|
N/A | |
| Completed |
NCT05621694 -
Exploring Oxytocin Response to Meditative Movement
|
N/A | |
| Completed |
NCT05688917 -
Green Coffee Effect on Metabolic Syndrome
|
N/A | |
| Recruiting |
NCT05575453 -
OPTIMA-BP: Empowering PaTients in MAnaging Blood Pressure
|
N/A |