Hypertension Clinical Trial
Official title:
A Short Term Open, Randomized Cross Over Trial Trial Exploring the Effect of Carbonic Anhydrase Inhibition by Acetazolamide on Sleep Apnea Associated Hypertension
This is a short term open, randomized cross over trial to explore and compare the efficacy
of pharmacological carbonic anhydrase (CA) inhibition on obstructive sleep apnea (OSA)
related hypertension. Patients will be randomized to receive Acetazolamide(Diamox®)(ACZ),
Continuous Positive Airway Pressure (CPAP)or CPAP plus ACZ for 2 weeks. Following a 2 week
wash-out period all study participants will receive the alternative treatment regimen. The
total length of the study will be 10 weeks. The effects of carbonic anhydrase inhibition on
blood pressure,hemodynamics and sleep apnea will be investigated.
Study hypothesis:
Carbonic anhydrase inhibition alone or in combination with nCPAP will prominently reduce
blood pressure in patients with OSA. Further it is hypothesized that CA inhibition will
induce a direct pharmacological effects on vascular stiffness as evidenced in overnight
non-invasive assessments of vascular stiffness and that this effect will be particularly
strong in patients also responding with a reduction of blood pressure.
n/a
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
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